A new chemotherapy regimen appears to produce minimal side effects in patients with lung cancer that has not responded to previous therapy, paving the way for additional research to determine if the new regimen also helps shrink tumors, according findings to be presented by Fox Chase Cancer Center researchers at the AACR Annual Meeting 2013...
Two studies funded by NASA and presented at the AACR Annual Meeting 2013 help explain why space radiation may increase the risk of colorectal cancer in humans...
A new preclinical technology enables researchers to quickly determine if a particular treatment is effective against gastrointestinal stromal tumors (GISTs), providing a boost to animal research and possibly patient care, according to new findings presented by Fox Chase Cancer Center at the AACR Annual Meeting 2013...
Study Identifies A Protein That Helps Trigger Both Normal Fetal Growth And Cancer
4/11/2013
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers. The work, conducted using mouse and human tissue, appears in the Proceedings of the National Academy of Sciences...
Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people to chemotherapy-induced peripheral neuropathy, a condition that is hard to predict and often debilitating enough to cause cancer patients to stop their treatment early...
Neuroblastomas Vulnerable To Novel Class Of Drugs May Be Identified By Genetic Biomarker
4/11/2013
An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists reported at the annual meeting of the American Association for Cancer Research in Washington, April 6-10...
In Pediatric Bone Cancer, K9 Osteosarcoma Samples Identify Drivers Of Metastasis
4/11/2013
Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the disease every year...
Promising Phase I Clinical Trial Of Rogosertib Leads To Multi-Institutional Phase II Trial
4/11/2013
Results of a phase 1 clinical trial reported at the American Association for Cancer Research (AACR) annual conference show that orally administered Rigosertib is well tolerated in patients with advanced solid tumors. This is the first trial in which orally administered Rigosertib, a dual kinase inhibitor, was studied in solid tumors...
Understanding How Oncogenes Affect The Body Clock May Help Create Better Cancer Treatments
4/11/2013
The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells...
A Promising Drug Can Help Prevent Head And Neck Cancers
4/11/2013
Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions...