Discovery Of Signature Of Circulating Breast Tumor Cells That Metastasize To The Brain
4/12/2013
Some breast tumor circulating cells in the bloodstream are marked by a constellation of biomarkers that identify them as those destined to seed the brain with a deadly spread of cancer, said researchers led by those at Baylor College of Medicine in a report that appears online in the journal Science Translational Medicine...
Overwhelming Evidence Adds A Major New Target In Breast Cancer: Androgens Including Testosterone
4/12/2013
Estrogen and progesterone receptors, and the gene HER2 - these are the big three markers and/or targets in breast cancer. Evidence presented at the AACR Annual Meeting 2013 adds a fourth: androgen receptors...
Reactivation Of Six2 Homeoprotein Allows Breast Cancer Cells To Detach And Metastasize
4/12/2013
In results presented at the AACR Annual Meeting 2013, researchers from the University of Colorado Cancer Center show that the Six2 homeoprotein, while not involved in primary tumor growth, allows cells to detach from substrate and survive their transition through the bloodstream to faraway sites of metastasis. "Here we show for the first time that Six2 causes breast cancer progression...
Drug Combination Of MK-1775 And Gemcitabine More Effective In Treating Sarcomas
4/12/2013
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have found that when given together, a two-drug combination acts synergistically in test animals modeled with sarcoma tumors. They report that the drug combination of MK-1775 and gemcitabine resulted in a 70 percent decrease in the tumor volume when compared to receiving one drug or the other...
Auto Pollution Exposure May Be Linked To Some Childhood Cancers
4/12/2013
Scientists from UCLA's Fielding School of Public Health led by Julia Heck, an assistant researcher in the school's epidemiology department and a member of UCLA's Jonsson Comprehensive Cancer Center, have found a possible link between exposure to traffic-related air pollution and several childhood cancers...
Positive Clinical Data Presented For Lead Accurin Candidate BIND-014 In Cancer Patients
4/12/2013
BIND Therapeutics, a clinical-stage biopharmaceutical company developing a new class of highly selective targeted and programmable therapeutics called AccurinsTM, has announced that positive Phase 1 clinical data for BIND-014, the company's lead drug candidate, were presented in an oral presentation at the American Association for Cancer Research (AACR) 2013 Annual Meeting...
"Death With Dignity" Program Is Rarely Used
4/11/2013
Doctors, patients, and their families have been okay with a "Death with Dignity" physician-assisted suicide program that is available to patients with fatal cancer at a Seattle clinic, a study suggests...
Melanoma Succumbs To Natural Plant Substance Gossypin In Lab Tests
4/11/2013
For the first time, using lab tests on cell cultures and mice, researchers in the US have shown that gossypin, a naturally-occurring substance found in plants, may be an effective treatment against melanoma, the deadliest form of skin cancer...
New Target Plus New Drug Equals Death Of Melanoma Cells
4/11/2013
Collaborative research presented by the University of Colorado Cancer Center, the University of North Carolina at Chapel Hill, Harvard Medical School and the University of Pittsburgh, at the American Association for Cancer Research (AACR) Annual Conference, shows that the protein receptor Mer is overexpressed in melanoma and that the investigational drug UNC1062 blocks Mer surv...
Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes...