Mutations found in the tumor suppressor gene TP53 in 90 percent of osteosarcomas, by the St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, suggesting the alteration plays a key role early in development of the bone cancer. The research was published online ahead of print in the journal Cell Reports.
Inhibiting cancer-promoting prolactin causes unconventional cell death in preclinical research
4/08/2014
Some cancer cells under stress from chemotherapy or radiation, dodge death by consuming a bit of themselves, allowing them to essentially sleep through treatment and later awaken as tougher, resistant disease.
Obese fathers produce heavier daughters with epigenetically altered breast tissue in mouse model
4/08/2014
The findings, presented by a Georgetown Lombardi Comprehensive Cancer Center researcher at the AACR Annual Meeting 2014, come from one of the first animal studies to examine the impact of paternal obesity on future generations' cancer risk.
Quick, simple blood test for solid cancers looks feasible
4/07/2014
The idea of a general, quick and simple blood test for a diverse range of cancers just came closer to reality with news of a new study published in Nature Medicine.Researchers from Stanford University School of Medicine have devised an ultra-sensitive method for finding DNA from cancer tumors in the bloodstream.
Genetic regulator identified as possible treatment target in melanoma
4/07/2014
Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.
Patients with cancer of the throat and who are positive for the Human Papilloma virus (HPV+) have a good prognosis, but until now the effect of being HPV+ on the prognosis of tumours located elsewhere in the head and neck was unknown.
Helium ions may provide superior, better-targeted treatment in paediatric radiotherapy
4/07/2014
For the first time, researchers have been able to demonstrate that the use of helium ions in radiation therapy could provide accurate treatment to tumours while helping to spare healthy organs.
Major added benefit of Radium-223 dichloride for certain prostate cancer patients
4/07/2014
Patients survive longer and get bone symptoms later / no evaluable data in comparison with docetaxelRadium-223 dichloride (radium-223 for short, trade name: Xofigo) has been approved since November 2013 for men with advanced prostate cancer, in whom hormone blockade is no longer effective, and symptomatic bone metastases, but without visceral metastases.
Remote-controlled nanoparticles cause cancer cells to self-destruct
4/07/2014
According to research from Lund University in Sweden, using magnetically controlled nanoparticles to force tumour cells to 'self-destruct' sounds like science fiction, but could be a future part of cancer treatment."The clever thing about the technique is that we can target selected cells without harming surrounding tissue.
New test could accurately predict prostate cancer recurrence
4/07/2014
Researchers have created a test that they say can predict whether a man is at high risk of prostate cancer recurrence.The research team, led by Prof. Robert Bristow of the Princess Margaret Cancer Centre and the University of Toronto, both in Canada, presented their findings at the 33rd conference of the European Society for Radiotherapy and Oncology (ESTRO33) in Vienna, Italy.