Red Wine Versus White Wine - Comparison Of Effects On Hormones Related To Breast Cancer Risk
1/22/2012
Aromatase inhibitors (AIs) prevent the conversion of androgens to estrogens, and could play a role in the development of breast cancer. This study of 36 pre-menopausal women consisted of a cross-over intervention trial to determine if there were differences between red wine and white wine in their effects on AIs...
Inherited Mutation Links Exploding Chromosomes To Cancer
1/21/2012
An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University Hospital, all in Heidelberg, Germany, have discovered...
Small Changes In The Genome Account For Gender Differences In Liver Cancer Risk
1/21/2012
Men are four times more likely to develop liver cancer compared to women, a difference attributed to the sex hormones androgen and estrogen. Although this gender difference has been known for a long time, the molecular mechanisms by which estrogens prevent - and androgens promote - liver cancer remain unclear...
Tumor Growth Not Halted By Cell Senescence
1/21/2012
A collaboration between a cancer biologist from the University of Milano and 2 physicists has shown that cell senescence occurs spontaneously in melanoma cells, but does not stop their growth Since cancer cells grow indefinitely, it is commonly believed that senescence could act as a barrier against tumor growth and potentially be used as a way to treat cancer...
Novel Gene Mutations Associated With Bile Duct Cancer Could Lead To Targeted Treatment
1/21/2012
Investigators at the Massachusetts General Hospital (MGH) Cancer Center have identified a new genetic signature associated with bile duct cancer, a usually deadly tumor for which effective treatment currently is limited...
Cholesterol-Lowering Statins May Treat Breast Cancer
1/21/2012
Cholesterol-lowering statins seem to keep breast cancer at bay in some patients. Now researchers reporting in the January 20th issue of the journal Cell, a Cell Press publication, provide clues about how statins might yield those unexpected benefits. The findings also suggest that mutations in a single gene could be used to identify tumors likely to respond to statin therapy...
New Drug Labels For Kidney Disease Patients
1/21/2012
The U.S. Food and Drug Administration (FDA) recently recommended that clinicians be more conservative when they prescribe chronic kidney disease (CKD) patients with drugs that treat red blood cell deficiencies. But the drug label's recommendations fall short, according to two commentaries appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN)...
Tumor Growth Not Halted By Cell Senescence
1/21/2012
A collaboration between a cancer biologist from the University of Milano and 2 physicists has shown that cell senescence occurs spontaneously in melanoma cells, but does not stop their growth Since cancer cells grow indefinitely, it is commonly believed that senescence could act as a barrier against tumor growth and potentially be used as a way to treat cancer...
Regorafenib Does Well In Metastatic Colorectal Trial
1/20/2012
The latest results on Bayer HealthCare's investigational compound regorafenib (BAY 73-4506) from the international, multicenter, randomized, double-blind, placebo-controlled Phase III CORRECT (Colorectal cancer treated with regorafenib or place after failure of standard therapy) trial have been announced by Bayer HealthCare...
Aspirin - Ability To Prevent Cervical Cancer In HIV Infected Women
1/20/2012
According to a study published in the current issue of the journal Cancer Prevention Research, aspirin should be assessed for its ability to prevent cervical cancer developing in women infected with HIV. Aspirin has the potential to provide considerable benefit for women in Africa, the Caribbean and Latin America, regions where death rates from cervical cancer are extremely high...