News From The Journal Of Clinical Investigation: March 12, 2012
3/13/2012
ONCOLOGY New Determinant of Human Breast Cancer Metastasis Discovered Researchers at the University of Kentucky's Markey Cancer Center in Lexington, KY have provided new insight as to why the most severe subtype of breast cancer in humans frequently metastasizes...
Insulin, Nutrition Found To Prevent Blood Stem Cell Differentiation In Fruit Flies
3/13/2012
UCLA stem cell researchers have shown that insulin and nutrition keep blood stem cells from differentiating into mature blood cells in Drosophila, the common fruit fly, a finding that has implications for studying inflammatory response and blood development in response to dietary changes in humans...
Possible Protection Against Prostate Cancer Through Circumcision
3/13/2012
A new analysis led by researchers at Fred Hutchinson Cancer Research Center has found that circumcision before a male's first sexual intercourse may help protect against prostate cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study suggests that circumcision can hinder infection and inflammation that may lead to this malignancy...
Antidepressant Shows Promise As Cancer Treatment
3/13/2012
A retinoid called all-trans retinoic acid (ATRA), which is a vitamin A-derivative, is already used successfully to treat a rare sub-type of acute myeloid leukemia (AML), however this drug has not been effective for the more common types of AMLs. Team leader Arthur Zelent, Ph.D., and colleagues at the ICR have been working to unlock the potential of retinoids to treat other patients with AML...
Discovery Could Reduce Chemo's Side Effects
3/13/2012
A team of researchers at Duke University has determined the structure of a key molecule that can carry chemotherapy and anti-viral drugs into cells, which could help to create more effective drugs with fewer effects to healthy tissue...
Childhood Cancer Linked To Developmental Delays In Milestones
3/13/2012
Infants and toddlers who have been treated for cancer tend to reach certain developmental milestones later than do their healthy peers, say researchers at the National Institutes of Health and in Italy. The findings show that delays may occur early in the course of treatment and suggest that young children with cancer might benefit from such early interventions as physical or language therapy...
Making Personalized Cancer Therapies More Cost Effective
3/13/2012
As scientists continue making breakthroughs in personalized cancer treatment, delivering those therapies in the most cost effective manner has become increasingly important. Now researchers at the University of Colorado School of Medicine have identified new ways of doing just that, allowing more patients to benefit from this revolution in cancer care...
Colorectal Cancer For Under 50s On The Rise
3/12/2012
Whilst colorectal cancer cases are generally on the decline since the beginning of the millennium, there seems to be an alarming rise in those under 50 hit by the disease. Since 1992, the number of people diagnosed with colorectal cancer has risen by two percent per year...
Circumcision Linked To Lower Prostate Cancer Risk
3/12/2012
An interesting and relatively simple piece of research into prostate cancer has been released this week. It is one that you might have thought would have been done a lot sooner. The paper shows evidence that supports circumcision in reduction of prostate cancer risk...
Abscopal Effect - When Radiation Also Destroys Non Targeted Tumors
3/12/2012
In the March 8 issue of the New England Journal of Medicine, a team of researchers at Memorial Sloan Kettering Cancer Center report on an extremely rare phenomenon known as the abscopal effect, in cancer patients with melanoma, treated with the immunotherapeutic agent ipilimumab (Yervoy™). The study was conducted at Memorial Sloan Kettering's Ludwig Center for Cancer Immunotherapy...