Advanced-Stage Neuroblastoma Diagnosis Age Linked To Genetic Mutation
3/13/2012
In children and young adults with advanced-stage neuroblastoma (a cancerous tumor that develops from nerve tissue), researchers have identified that certain variations of the gene ATRX are associated with age at diagnosis. The study is published in the March 14 issue of JAMA. In children, neuroblastoma is the most prevalent extracranial (outside the cranium) solid tumor...
Severity Of Acute Graft Vs. Host Disease Governed By Mini-Molecule
3/13/2012
Researchers have identified a molecule that helps control the severity of graft-versus-host disease, a life-threatening complication for many leukemia patients who receive a bone-marrow transplant. The study, led by researchers with the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J...
Selective Neck Dissection In Laryngeal Squamous Cell Carcinoma
3/13/2012
Metastasis of tumors to level IIb lymph nodes is rare in patients with laryngeal squamous cell carcinoma (LSCC); this area can be ignored during selective neck dissection (SND) to avoid damaging the spinal accessory nerve (SAN), making this surgery more conservative and minimizing SAN morbidity, according to the March 2012 issue of Otolaryngology-Head and Neck Surgery...
DNA Chaos In Red Blood Cells Caused By Defect In Transport System
3/13/2012
Within all our cells lies two meters of DNA, highly ordered in a structure of less than 10 micro meters in diameter. Special proteins called histones act as small building bricks, organising our DNA in this structure. Preservation of the structure is necessary to maintain correct function of our genes, making histones detrimental for maintaining a healthy and functional body...
Improving Survival Reported By Largest Ever Study Of Childhood Acute Lymphoblastic Leukemia
3/13/2012
A 21,626-person study publishedin the Journal of Clinical Oncology found that the five-year survival rate for children and adolescents with acute lymphoblastic leukemia (ALL), the most common childhood cancer, improved from 83.7 percent in those diagnosed during the years 1990-1994, to 90.4 percent for those diagnosed in the years 2000-2005...
Worries About Quality Of Colon Cancer Screening Follow Pressures To Increase Volume Of Colonoscopies
3/13/2012
Researchers at Mount Sinai School of Medicine have found that 92 percent of more than 1,000 gastroenterologists responding to a survey believed that pressures to increase the volume of colonoscopies adversely impacted how they performed their procedures, which could potentially affect the quality of colon cancer screening...
Pockets Of High Cervical Cancer Rates In North Carolina Identified By Study
3/13/2012
A study of cervical cancer incidence and mortality in North Carolina has revealed areas where rates are unusually high. The findings indicate that education, screening, and vaccination programs in those places could be particularly useful, according to public health researchers at the University of North Carolina at Chapel Hill, who authored the report...
Discovery Explains How A Class Of Chemotherapy Drugs Works
3/13/2012
The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman calls in executioners to annihilate a cell...
Preventing Bladder Cancer From Metastasizing To Lungs
3/13/2012
The diagnosis of localized bladder cancer carries an 80 percent five-year survival rate, but once the cancer spreads, the survival rate at even three years is only 20 percent. A major study published in the Journal of Clinical Investigation not only shows how bladder cancer metastasizes to the lungs but pinpoints a method for stopping this spread...
Link Between Red Meat Consumption And Increased Risk Of Total, Cardiovascular, And Cancer Mortality
3/13/2012
A new study from Harvard School of Public Health (HSPH) researchers has found that red meat consumption is associated with an increased risk of total, cardiovascular, and cancer mortality. The results also showed that substituting other healthy protein sources, such as fish, poultry, nuts, and legumes, was associated with a lower risk of mortality...