Addiction History In Smokers' DNA May Show Cancer Risk
11/07/2012
Smokers leave a chemical "footprint" of their addiction history on the surface of their DNA, and this may serve as a measure of their risk for developing cancer, say researchers from the UK and Italy who presented their findings at a conference in Liverpool, UK, this week...
Researchers from Aarhus University, Denmark, have now discovered an important mechanism behind one of our most fundamental lines of immune function. The discovery has been published in the esteemed scientific journal, The Journal of Immunology, where it has been highlighted as a top story...
How Second Species Of Mole Rat Wards Off Cancer
11/07/2012
Biologists at the University of Rochester have determined how blind mole rats fight off cancer - and the mechanism differs from what they discovered three years ago in another long-lived and cancer-resistant mole rat species, the naked mole rat...
Discovery of A Chink In The Armor Of Cancer Cells
11/07/2012
Several substances inhibiting so-called HDAC enzymes have been studied in trials searching for new anti-cancer drugs in recent years. "Trials have shown that HDAC inhibitors are very effective in arresting growth of cultured cancer cells. But apart from a very rare type of lymphoma, these drugs unfortunately do not clinically affect malignant tumors," says Prof. Dr...
Gene therapy can be performed safely in the human salivary gland, according to scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health. This finding comes from the first-ever safety, or Phase I, clinical study of gene therapy in a human salivary gland...
News From The Annals Of Internal Medicine: 5 Nov. 2012
11/06/2012
1. Follow Up Surveillance with Less Invasive, Less Costly Tests Could Make Colonoscopy a One-time Test for Some Patients Following a negative colonoscopy result at initial screening, regular follow-up with less-invasive screening tools may provide the same life-saving benefit with fewer risks for complication and at a lower cost than rescreening with colonoscopy every 10 years...
RNA-Based Nanotechnology Promising For Overcoming Endocrine-Resistant Breast Cancer
11/06/2012
A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease...
New Target Identified For Lung Cancer Treatment
11/05/2012
A team of UC Davis investigators has discovered a protein on the surface of lung cancer cells that could prove to be an important new target for anti-cancer therapy. A series of experiments in mice with lung cancer showed that specific targeting of the protein with monoclonal antibodies reduced the size of tumors, lowered the occurrence of metastases and substantially lengthened survival time...
Predicting how atherosclerosis, osteoporosis or cancer will progress or respond to drugs in individual patients is difficult. In a new study, researchers took another step toward that goal by developing a technique able to predict from a blood sample the amount of cathepsins - protein-degrading enzymes known to accelerate these diseases - a specific person would produce...
Survival Of Breast Cancer Patients With Brain Metastases May Be Improved By Combination Treatment
11/05/2012
Adding an angiogenesis inhibitor to treatment with a HER2-inhibiting drug could improve outcomes for patients with HER2-positive breast cancer who develop brain metastases...