Scientists Reveal Cell Surface Transporters Exploited For Cancer Drug Delivery
12/04/2012
Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant cells. In such an approach, the overexpression of specific transporters could be exploited to deliver toxic substances into cancer cells...
Neuroblastoma Patients With ARID1A And ARID1B Mutations Have More Aggressive Disease
12/04/2012
In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes...
How 2 Proteins Help Keep Cells Healthy Has Implications For Cancer Drug Development
12/04/2012
The study, published online ahead of print by the journal Nature Structural & Molecular Biology, focuses on the structure and function of the two proteins, ATG12 and ATG5. These proteins need to bond correctly to form an organelle called the autophagosome, which acts like a trash bag that removes toxic materials and provides the cell with nutrition through recycling...
2 Gene Mutations Identified In Neuroblastoma
12/04/2012
Using powerful gene-analysis tools, researchers have discovered mutations in two related genes, ARID1A and ARID1B, that are involved in the most aggressive form of the childhood cancer neuroblastoma...
Master Regulator Of Skin Development Discovered
12/04/2012
The surface of your skin, called the epidermis, is a complex mixture of many different cell types - each with a very specific job. The production, or differentiation, of such a sophisticated tissue requires an immense amount of coordination at the cellular level, and glitches in the process can have disastrous consequences...
Very Promising Results For Leukemia Patients From Clinical Trial Of Ponatinib
12/04/2012
Huntsman Cancer Institute (HCI) researchers Michael Deininger, M.D., Ph.D., and Thomas O'Hare, Ph.D., were part of a team that found a potent oral drug, ponatinib, effective in patients who have developed resistance to standard treatments for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic lymphoma (Ph+ ALL)...
Mistletoe - The Kiss Of Death To Cancer?
12/04/2012
Mistletoe has become an important symbol of Christmas but it also has the potential to play a vital role as an alternative therapy for sufferers of colon cancer. At the University of Adelaide in Australia, scientists are interested in how the extract of mistletoe could either assist chemotherapy or act as an alternative to chemotherapy as a treatment for colon cancer...
Possible Road Map For Improving Healthcare Provided By Intermountain Healthcare Cancer Research
12/04/2012
A series of studies directed by Intermountain Healthcare's Oncology Clinical Program shows that it's possible to improve care across the board if you tackle the problem in a standardized way, relying on the best evidence available Given the right equipment, training and skill, an individual surgeon can expect to provide the best possible care on a consistent basis...
Diabetes Drug Could Also Help Treat Ovarian Cancer
12/03/2012
Patients with diabetes who also have ovarian cancer and take the drug metformin for the treatment of their diabetes, have a greater survival rate than patients who do not take it, a new study published in the journal Cancer suggests. These new findings could potentially guide researchers as they continue to explore the use of existing medications to treat new or different diseases...
Diabetes Drug Could Also Help Treat Ovarian Cancer
12/03/2012
Patients with diabetes who also have ovarian cancer and take the drug metformin for the treatment of their diabetes, have a greater survival rate than patients who do not take it, a new study published in the journal Cancer suggests. These new findings could potentially guide researchers as they continue to explore the use of existing medications to treat new or different diseases...