Blocking a specific protein renders tumors more vulnerable to treatment in mice, suggesting new therapies could eventually achieve the same in humans, according to new research from Fox Chase Cancer Center, presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium...
Protein Controlling Glucose Metabolism Also A Tumor Suppressor
12/11/2012
A protein known to regulate how cells process glucose also appears to be a tumor suppressor, adding to the potential that therapies directed at cellular metabolism may help suppress tumor growth. In their report in the Dec...
In Women Whose Breast Cancer Has Spread, Study Compares Standard Against Newer Treatment
12/11/2012
Results from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate with capecitabine, a standard drug used for chemotherapy today in women with previously treated metastatic breast cancer, showed that eribulin demonstrated a trend toward improved overall survival. This study was presented by Peter A. Kaufman, M.D...
A Safe And First-Line Treatment For Metastatic Breast Cancer?
12/11/2012
Previous research has shown that a family of genes, proteins and enzymes called the uPA system (for urokinase plasminogen activator) plays an active role in different facets of cancer's biology, including tumor cell invasion, the spread of metastases, and the growth of a primary tumor. Mesupron® is a new small molecule inhibitor, taken as a pill, that inhibits the uPA system...
More Breast Cancer Patients Could Benefit From Existing Drugs
12/11/2012
More patients can benefit from highly effective breast cancer drugs that are already available, according to DNA sequencing studies by researchers at Washington University School of Medicine in St. Louis and other institutions...
Breast Tumor Growth And Progression Promoted By Obesity And Overeating During Menopause
12/11/2012
Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research...
Genes Identified That Predict Whether Trastuzumab Will Work For Breast Cancer Patients
12/11/2012
Adding the drug trastuzumab to chemotherapy prevents cancer recurrence and improves survival in a large number of women with early stage HER2-positive breast cancer. But trastuzumab does not stop tumors from returning in about 25 percent of patients - and oncologists haven't been able to identify these women before treatment...
Research On Blood Vessel Proteins Holds Promise For Controlling 'Blood-Brain Barrier'
12/11/2012
Working with mice, Johns Hopkins researchers have shed light on the activity of a protein pair found in cells that form the walls of blood vessels in the brain and retina, experiments that could lead to therapeutic control of the blood-brain barrier and of blood vessel growth in the eye...
Leukemia Patients Stay In Remission More Than Two Years With New T Cell Therapy
12/10/2012
Leukemia patients who received infusions of their own T cells, after the cells had been genetically engineered to fight the patients' cancerous tumors, reacted to the therapy in a positive way, staying in full remission for over two years...
Study Identifies Targeted Molecular Therapy For Untreatable NF1 Tumors
12/10/2012
Researchers conducting a preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors that develop in people with the genetic disorder Neurofibromatosis 1 (NF1). Scientists from Cincinnati Children's Hospital Medical Center report their findings online Dec. 10 in the Journal of Clinical Investigation...