Angiocidin Found To Be Effective Against Leukemia
12/11/2012
Angiocidin, a novel tumor-inhibiting protein, has been shown to reduce acute myeloid leukemia (AML) cells in vivo by almost two-thirds in pre-clinical experiments. George P. Tuszynski, a professor of neuroscience in Temple University's School of Medicine who discovered Angiocidin, presented the findings during the American Society of Hematology's national meeting in Atlanta...
The promising investigational targeted therapy ibrutinib and its mechanism of silencing gene communication pathways critical to the development of cancer may be an effective way to combat chronic lymphocytic leukemia (CLL), according to studies presente at the 54th Annual Meeting of the American Society of Hematology (ASH)...
Blood Cancer Studies Assess Genetics, Modified Treatment To Improve Outcomes, Reduce Toxicity
12/11/2012
Research identifying genetic factors that affect survival of patients with blood cancers and evaluating the effectiveness of modified treatment strategies to improve outcomes while reducing toxicity were presented at the 54th Annual Meeting of the American Society of Hematology (ASH)...
Response To Therapy High For Experimental Agent Ibrutinib In Chronic Lymphocytic Leukemia Patients
12/11/2012
Updated results from a Phase Ib/II clinical trial indicates that a novel therapeutic agent for chronic lymphocytic leukemia (CLL) is highly active and well tolerated in patients who have relapsed and are resistant to other therapy. The agent, ibrutinib (PCI-32765), is the first drug designed to target Bruton's tyrosine kinase (BTK), a protein essential for CLL-cell survival and proliferation...
Positive Early Results In Clinical Trial For DNA Vaccine To Treat Leukaemia
12/11/2012
Early results of a trial to treat leukaemia with a WT1 DNA vaccine, has shown robust vaccine-specific antibody responses in all vaccinated patients evaluated to date. Furthermore, T cell immune responses, including those of the "killer T cells," were detected. Antibody and T cell responses are strong signals of the DNA vaccine's potential to treat the disease...
Diverse Genetic Alterations Discovered In Triple-Negative Breast Cancers
12/11/2012
Most triple-negative breast cancer patients who were treated with chemotherapy to shrink the tumor prior to surgery still had multiple genetic mutations in their tumor cells, according to a study by Vanderbilt-Ingram Cancer Center (VICC) investigators...
Novel 3-D Culture System Developed For Inflammatory Breast Cancer
12/11/2012
Inflammatory breast cancer (IBC) is a very rare and aggressive disease that progresses rapidly and is associated with a very low survival rate. To understand how this type of cancer spreads, it's crucial to characterize the interactions between cancer cells and their 3D environment...
Clotting Disorders: Studies Challenge Standards To Improve Treatment Outcomes
12/11/2012
Studies presented at the 54th Annual Meeting of the American Society of Hematology (ASH) examine current treatment standards for patients with clotting disorders in an effort to improve outcomes. The studies evaluate long-held treatment standards and whether modifications in intensity and duration of therapy may offer equally effective outcomes while reducing toxicities and relapse rates...
Extended Use Of Zytiga Approved By FDA For Late-Stage Prostate Cancer
12/11/2012
Today the U.S. Food and Drug Administration (FDA) lengthened the approved use of Zytiga (abiraterone acetate) as treatment for men with late-stage, castration-resistant prostate cancer (metastatic) before undergoing chemotherapy. First approved in 2011, Zytiga is used in patients whose prostate cancer developed further after treatment with docetaxel, a chemotherapy drug...
Outcomes In Head And Neck Cancer And Relationship To The Treating Institution
12/11/2012
Patients with head and neck cancer receiving radiation treatment at an academic center have a higher survival rate than those receiving treatment at a community center, according to a study in the December 2012 issue of Otolaryngology-Head and Neck Surgery...