Temple Researcher Shows Diabetes, Blood Pressure Link To Colon Cancer Recurrence, Survival
12/24/2012

By all accounts, a combination of colon cancer, diabetes and high blood pressure can be a recipe for medical disaster. Now, a new study led by a surgical oncologist and researcher at Temple University School of Medicine and Fox Chase Cancer Center has shown just how deadly this mix can be...

News From The Journal Of Clinical Investigation: Dec. 21, 2012
12/24/2012

The X-factor in liver metabolism After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway contributes to the liver's metabolic switch...

"Trojan Horse" Cancer Treatment Eliminates Cancer In Mice
12/24/2012

An experimental treatment that uses white blood cells like "Trojan horses" to carry a tumor-busting virus, completely abolished prostate cancer spread after chemo or radiotherapy in mice. The researchers hope clinical trials in human patients with prostate cancer can start in early 2013...

Researchers Find Model System To Study Promising Cancer Drug
12/24/2012

Researchers have found that the budding yeast (Saccharomyces cerevisiae) is an acceptable model system to study KP1019, an anti-cancer drug that uses ruthenium, a rare metal, a new study found. Researchers had previously been interested in studying KP1019 because it is believed to cause cancer cell death and is not known to have negative secondary side effects for healthy tissues...

New Technology Allows Scientists To Capture And Preserve Cancer Cells Circulating In The Bloodstream
12/24/2012

Scientists from the RIKEN Advanced Science Institute in Japan and University of California Los Angeles report a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream...

Changes In Progenitor Cell Population In Breast May Be Overlooked Factor In Breast Cancer
12/24/2012

The DNA mutations that accumulate over time as women age are not the sole contributor to the higher frequency of breast cancer in women over 50, Mark LaBarge, PhD, a researcher at Lawrence Berkeley National Laboratory (LBNL) reported on Dec. 17 in a presentation at the American Society for Cell Biology Annual Meeting in San Francisco...

To Revert Breast Cancer Cells, Give Them The Squeeze
12/24/2012

Researchers at the University of California, Berkeley, and the Lawrence Berkeley National Laboratory have put the squeeze - literally - on malignant mammary cells to guide them back into a normal growth pattern. The findings, presented Monday, Dec...

Study Uncovers Mechanism Used By BRCA1 To Suppress Tumors
12/24/2012

A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth. The findings, published online in Oncogene, focus on the gene BRCA1, which is mutated in a majority of families who have hereditary breast and/or ovarian cancers, according to senior author Ronit I...

Surviving Sepsis With LECT2
12/24/2012

Failure to launch an adequate immune response may be at the root of septic shock, according to a study published in The Journal of Experimental Medicine on December 17th. Bacterial sepsis is a potentially deadly blood infection that results in massive immune activation and inflammation. Sepsis therapies have traditionally focused on quelling this exaggerated inflammatory response...

UK Colonoscopy Guidelines May Better Identify High-Risk Patients
12/23/2012

Colonoscopy guidelines from the United Kingdom may better identify patients who need short-interval follow-up screening compared to guidelines from the United States. Researchers analyzed four prospective studies of 3,226 postpolypectomy patients to compare risk for advanced colorectal neoplasia at one-year colonoscopy. Patients were cross-classified by U.S. and U.K. surveillance guidelines...