Tumor Boards Linked To Little Association With Effects On Cancer Care
12/28/2012
There is little association of multidisciplinary tumor boards with measures of use, quality, or survival, and measuring only the presence of tumor boards may not be adequate in determining their effects on cancer care, according to a study published December 28 in the Journal of the National Cancer Institute...
Inability To Metabolize Tamoxifen Changes Breast Cancer Outcomes
12/28/2012
Breast cancer patients with a certain genetic liver enzyme alteration do not respond well to the hormone therapy tamoxifen as they have difficulty metabolizing the drug, leading to an increased risk of death and recurrence...
Cancer Screening Rates Have Fallen In US
12/28/2012
Despite evidence that earlier diagnosis and improved treatment increases survival, rates of people seeking preventive cancer screening have fallen in the US in the last ten years...
Heart Attack Patients Who Receive Blood Transfusion Have Higher Mortality Risk
12/28/2012
Heart attack patients who receive a blood transfusion are at a much higher risk of death than those who don't receive one, according to a report published in Archives of Internal Medicine. Anticoagulant and anti platelet drugs are often used to treat acute coronary syndrome which typically occurs during a heart attack...
Drug Shortage Linked To Cancer Relapse
12/27/2012
A drug shortage appears to have caused a higher rate of relapse among children, teens and young adults with Hodgkin lymphoma, researchers form St. Jude Children's Research Hospital reported this week. The scientists say this is the first example of the tragic consequences of the current drug shortage...
Spread Of Cancer Cells May Be Slowed By Targeting Of Protein
12/27/2012
The spread of cancer cells may be slowed by targeting the protein km23-1, according to researchers at Penn State College of Medicine. A motor protein that transports cargo within the cell, km23-1 is also involved in the movement or migration of cells. Migration is necessary for cancer to spread, so understanding this cell movement is important for development of better cancer treatments...
Rebuilding Blood Vessels Through Gene Therapy
12/27/2012
Diagnosed with severe coronary artery disease, a group of patients too ill for or not responding to other treatment options decided to take part in a clinical trial testing angiogenic gene therapy to help rebuild their damaged blood vessels...
Mayo Clinic Researchers Identify Enzyme Linked To Prostate Cancer
12/26/2012
Researchers at Mayo Clinic's campus in Florida have identified an enzyme specifically linked to aggressive prostate cancer, and have also developed a compound that inhibits the ability of this molecule to promote the metastatic spread of the cancer. Their study, published in the Dec. 18 online edition of Molecular Cancer Research, is the first to link the enzyme PRSS3 to prostate cancer...
Discovery Of New Pathways That Drive Metastatic Prostate Cancer
12/24/2012
Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients, according to a pre-clinical study published ahead of print in the Journal of Clinical Investigation by researchers at the Kimmel Cancer Center at Jefferson. The group, headed by Karen E. Knudsen, Ph.D...
Preventing Prostate Cancer Through Androgen Deprivation May Have Harmful Effects
12/24/2012
The use of androgen deprivation therapies to prevent precancerous prostate abnormalities developing into aggressive prostate cancer may have adverse effects in men with precancers with specific genetic alterations, according to data from a preclinical study recently published in Cancer Discovery, a journal of the American Association for Cancer Research...