Cholesterol Finding Offers New Way To Kill Lymphoma Without Chemotherapy
1/23/2013
How do you annihilate lymphoma without using any drugs? Starve it to death by depriving it of what appears to be a favorite food: HDL cholesterol. Northwestern Medicine® researchers discovered this with a new nanoparticle that acts like a secret double agent. It appears to the cancerous lymphoma cell like a preferred meal -- natural HDL...
Evolutionary Explanations For Why We Get Cancer
1/23/2013
Over 500 billion cells in our bodies will be replaced daily, yet natural selection has enabled us to develop defenses against the cellular mutations which could cause cancer. It is this relationship between evolution and the body's fight against cancer which is explored in a new special issue of the Open Access journal Evolutionary Applications...
Cancer Cells Aided By Enzyme To Avoid Genetic Instability
1/23/2013
Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in The Journal of Cell Biology...
Breast Cancer Recurrence Predictable With Blood Test
1/22/2013
Using a DNA marker that can be obtained via a blood test, researchers in Canada were able accurately to predict which women were more likely to see a recurrence of their breast cancer years later. Although more studies are needed to confirm their findings, they suggest they could complement current prognosis approaches based on tumor assessment...
New Test Predicted Presence Of Harmful BRCA Mutations
1/22/2013
Profile test demonstrated high sensitivity and specificity. Test results could aid in clinical decision making. May provide a quick, affordable alternative to current genetic testing...
Comprehensive Population-Based Study Conducted by Team at The Cancer Institute of New Jersey In what is believed to be the first study to describe the impact on men with a 'high' risk of bone fracture who are receiving long-term androgen deprivation therapy (ADT) for prostate cancer, new research from The Cancer Institute of New Jersey shows this population to have a higher f...
New Genetic Defects Found In High-Risk Childhood Leukemia Subtypes With Chromosomal Loss
1/22/2013
Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes. The findings also provide the first evidence of the genetic basis for this high-risk leukemia, which is known as hypodiploid acute lymphoblastic leukemia (ALL)...
Finding On Killer Cells Opens New Avenue For Combating AIDS, Cancer And Other Diseases
1/22/2013
A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting an immune attack against viruses, cancerous tumors and other damaged or infected cells...
Researcher Leads Large Multicenter Gene Sequencing Study Of Neuroblastoma
1/22/2013
An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene mutation - mutations that would suggest new targets for neuroblastoma treatment...
In 1953, Cambridge researchers Watson and Crick published a paper describing the interweaving 'double helix' DNA structure - the chemical code for all life. Now, in the year of that scientific landmark's 60th Anniversary, Cambridge researchers have published a paper proving that four-stranded 'quadruple helix' DNA structures - known as G-quadruplexes - also exist within the human genome...