Potential Drug Target For Infectious Disease Revealed By Scissor-Like Enzyme
4/08/2013
UT Southwestern Medical Center researchers report that a pathogen annually blamed for an estimated 90 million cases of food-borne illness defeats a host's immune response by using a fat-snipping enzyme to cut off cellular communication...
New Frontiers In Breast Cancer Screening
4/08/2013
Researchers at Moffitt Cancer Center predict that advancements in breast cancer screening will need a personalized touch because mammography is not a "one strategy fits all" technology. Their review "Beyond Mammography: New Frontiers in Breast Cancer Screening" appears in The American Journal of Medicine...
A study published in the New England Journal of Medicine recommends a dramatic shift in the way doctors treat metastatic prostate cancer. "These results have changed the way I treat patients," said Ian M. Thompson Jr., M.D., director of the Cancer Therapy & Research Center at The University of Texas Health Science Center at San Antonio and senior author on the international study...
Chemotherapy Found To Work In An Unexpected Way
4/07/2013
It's generally thought that anticancer chemotherapies work like antibiotics do, by directly killing off what's harmful. But new research published online in the Cell Press journal Immunity shows that effective chemotherapies actually work by mobilizing the body's own immune cells to fight cancer...
Abnormal Copy Numbers Characterises Prostate Cancer
4/06/2013
Non-invasive 'liquid biopsies' can find metastatic or recurrent prostate cancer, in a low cost assay suitable for most healthcare systems, finds research published in BioMed Central's open access journal Genome Medicine. Genomic signatures of prostate cancer, isolated from plasma DNA, display abnormal copy numbers of specific areas of chromosomes...
Genotype-Specific Targeted Therapies For Lung Cancer
4/06/2013
Physician-researchers at UT Southwestern Medical Center have identified a vulnerability of certain lung-cancer cells - a specific genetic weakness that can be exploited for new therapies. Although researchers have long known that mutant versions of the KRAS gene drive tumor formation and are key to cell survival in non-small cell lung cancer, the blocking of activated KRAS has proven difficult...
IDH1 And IDH2 Mutant Inhibitors Reverse Differentiation Blocks In Patient-Derived Tumor Samples
4/06/2013
Agios Pharmaceuticals, Inc...
One Specific MicroRNA Appears To Promote Tumor Growth And Cancer Spread
4/05/2013
Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in tumors, tumor inflammation, and metastasis. As a therapeutic target, miR-155 could potentially provide a new avenue of treatment when targeted with drugs to suppress its activity...
New Research Suggests Friendly Bacteria May Shrink Tumours
4/05/2013
Friendly bacteria commonly found in probiotic drinks could be used to shrink tumours, according to new research published in the International Journal of Medical Microbiology. Researchers, from the University of Ulster in Northern Ireland and Sonidel Ltd. in Dublin, Ireland, looked at the effect on tumours of the common Lactobacillus casei. L...
Fatty Acid Metabolite Shows Promise Against Cancer In Mice
4/05/2013
UC Davis discovery demonstrates mechanism in dietary omega-3 fatty acids (fish oils) A team of UC Davis scientists has found that a product resulting from a metabolized omega-3 fatty acid helps combat cancer by cutting off the supply of oxygen and nutrients that fuel tumor growth and spread of the disease...