First Stage Study Finds Potential New Drugs For Neuroblastoma
6/26/2013
Scientists at The Institute of Cancer Research, London have made a step towards new, targeted drugs for children with the highestrisk form of a childhood cancer called neuroblastoma. In a preclinical study, published in journal Cancer Cell , researchers successfully used two potential drugs to target cancerous neuroblastoma cells with an overactive gene called MYCN...
News From The Journal Of Clinical Investigation: June 24, 2013
6/26/2013
Gene dysregulation underlies preeclampsia Preeclampsia is a medical condition affecting 4-8% of pregnancies that is characterized by high maternal blood pressure, excess protein in maternal urine, and reduced fetal growth. If left untreated, it can develop into eclampsia, which causes life threatening seizures. Apart from delivery, there is no known cure...
Use of advanced treatment technologies for prostate cancer, such as intensitymodulated radiotherapy and robotic prostatectomy, has increased among men with lowrisk disease, high risk of noncancer mortality, or both, a population of patients who are unlikely to benefit from these treatments, according to a study in the June 26 issue of JAMA...
Gene Mutation May Have Effect On Benefit Of Aspirin Use For Colorectal Cancer
6/25/2013
In 2 large studies, the association between aspirin use and risk of colorectal cancer was affected by mutation of the gene BRAF, with regular aspirin use associated with a lower risk of BRAFwildtype colorectal cancer but not with risk of BRAFmutated cancer, findings that suggest that BRAFmutant colon tumor cells may be less sensitive to the effect of aspirin, according to a stu...
How Safe Is Splenda (Sucralose)?
6/25/2013
Splenda (sucralose) is being downgraded from "safe" to "caution" after an Italian animal study linked sucralose to a higher risk of developing leukemia. The Center for Science in the Public Interest (CSPI) says it awaits the Italian study's review before deciding what long-term safety grade to assign to Splenda in its Chemical Cuisine guide to food additives...
Breast Cancer: NHS Should Offer Women With Family History Preventive Drugs
6/25/2013
Nearly half a million women in England and Wales with a family history of breast cancer should be offered drugs via the NHS to help lower their risk of developing the disease, according to updated guidance by the National Institute for Health and Care Excellence (NICE) released on Tuesday...
Some Older Patients With Myelodysplastic Syndromes Benefit From Stem Cell Transplants
6/25/2013
A new study by an international team led by Dana-Farber Cancer Institute scientists provides the first statistically-based guidelines for determining whether a stem cell transplant is appropriate for older patients with myelodysplastic syndromes (MDS) - the most common blood disorders in people over 60 years of age, and frequently a precursor for leukemia...
A new discovery about how cells move inside the body may provide scientists with crucial information about disease mechanisms such as the spread of cancer or the constriction of airways caused by asthma...
Evaluating Drugs Aimed At Treating Sickle Cell Crisis Via Computer Models
6/25/2013
Using powerful computer models, researchers from Brown University have shown for the first time how different types of red blood cells interact to cause sickle cell crisis, a dangerous blockage of blood flow in capillaries that causes searing pain and tissue damage in people with sickle cell disease...
Performance Assessment Improves Quality Of Colonoscopy Procedures
6/25/2013
A new study reports that the use of a quarterly report card is associated with improved colonoscopy quality indicators. Endoscopists at the Roudebush Veterans Affairs Medical Center in Indianapolis, Ind., who participated in the study showed an overall adjusted adenoma (precancerous polyp) detection rate increase from 44.7 percent to 53.9 percent, and a cecal intubation rate increase from 95...