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Pediatric low-grade gliomas with CRAF fusions may require differential and combinatorial targeted therapies
11/06/2015

Unlike pediatric low-grade gliomas (PLGG) that are driven by BRAF fusionproteins, PLGGs that are driven by other forms of RAF fusion proteins, called CRAF fusionproteins, may not respond to...

New way to find DNA damage
11/06/2015

University of Utah chemists devised a new way to detect chemical damage to DNA that sometimes leads to genetic mutations responsible for many diseases, including various cancers and neurological...

TCGA findings provide molecular background for second most common kidney cancer
11/06/2015

Scientists with The Cancer Genome Atlas (TCGA), a National Institutes of Health-funded project, have molecularly characterized two types of the second most common kidney cancer and classified several...

Clinical trial examines oral cancer prevention
11/06/2015

Oral premalignant lesions (OPLs) are considered risk factors for the development of oral cancer. In an article published online by JAMA Oncology, William N. William Jr., M.D.

New breast cancer stem cell clues may help develop therapeutics
11/06/2015

Researchers have identified a new regulatory pathway that may play an important role in basal-like breast cancer (BLBC), a particularly aggressive form of breast cancer often referred to as "triple...

Researchers identify new route for release of steroid hormones
11/06/2015

Conventional 'free diffusion' model of steroid hormone release should be revisited, notes UC Riverside-led study; research could have health and agricultural benefits.

Medicines for breast cancer: The affordability controversy
11/06/2015

New and better drugs to treat diseases such as advanced breast cancer1 will have little effect on improving patient outcomes if a country does not have good healthcare structures in place, Professor...

DNA strands often 'wiggle' as part of genetic repair
11/06/2015

Sometimes, the molecules that make up life exhibit strange behavior. For instance, in simple organisms such as yeast, when genetic material becomes damaged, the affected DNA strands increase their...

Stem-cell scientists redefine how blood is made
11/06/2015

Toppling conventional 'textbook' view from 1960s.Stem-cell scientists led by Dr.

Temple researchers: Small molecule inhibitor shows promise in precision cancer targeting
11/06/2015

Cancer cells with mutations in BRCA1 or BRCA2 genes, which serve a vital role in preserving the integrity of the genetic code, are key targets for cancer therapeutics.