Epigenetic silencing of the HAND2 tumor suppressor promotes endometrial cancer
11/12/2013
A study published in PLOS Medicine suggests that epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer. HAND2 is active in the healthy endometrium (the tissue lining the uterus) where it antagonizes the growth-inducing effects of estrogen...
Breast cancer radiotherapy during surgery could ease treatment
11/12/2013
Two new studies published in leading journals this week show how a "one-stop" targeted radiotherapy given during lumpectomy may offer some patients with early-stage breast cancer a viable alternative to current treatments. Experts say the approach looks promising but more research is needed to identify which patients are most likely to benefit...
Accuray Incorporated (Nasdaq: ARAY), has announced the publication of two papers stemming from a large multi-center study of CyberKnife® stereotactic body radiotherapy (SBRT) led by investigators at the University of California, Los Angeles(UCLA)...
Study finds new explanation for resistance to breast cancer treatment
11/12/2013
Breast cancers that initially respond to hormone therapies such as tamoxifen eventually become resistant to treatment, and a new study finds this may be because of a mutation in the receptor present in the cancer cell to which tamoxifen binds, according to data published in Cancer Research, a journal of the American Association for Cancer Research...
Simple blood test for sub-type specific lung cancer diagnosis
11/12/2013
Lung cancer is the leading cause of cancer specific death worldwide. 85% lung cancers are non-small cell lung cancers (NSCLC) while remaining are small cell lung cancers (SCLC). Although X-Ray and CT scan remain the main non-invasive diagnosis strategy, the painful lung tissue biopsy is essential for confirmation and staging of the disease...
Histone demethylase associated with non-small cell lung cancer identified
11/12/2013
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer deaths worldwide. Current therapies that target cellular kinases have been effective for some patients: however, many individuals with NSCLS do not respond. Recent studies of other cancers indicate that the global changes in DNA methylation patterns may drive tumor formation...
TWEAK-Fn14 a key drug target for glioblastoma and other cancers
11/12/2013
A cellular pathway interaction known as TWEAK-Fn14, often associated with repair of acute injuries, also is a viable target for drug therapy that could prevent the spread of cancer, especially brain cancer, according to a study led by the Translational Genomics Research Institute (TGen)...
Potential drug target may nip cancer in the bud
11/12/2013
Scientists at A*STAR have discovered an enzyme, Wip1 phosphatase, as a potential target to weed out the progression of cancer. Although studies in the past have revealed that this enzyme plays a critical role in regulating the budding of tumours, scientists have for the first time unearthed a mechanism for its mode of action...
Discovery of racial difference in blood clotting warrants a closer look at heart attack medications
11/12/2013
Thomas Jefferson University researchers have discovered that the formation of blood clots follows a different molecular route in African Americans versus European Americans, providing a new understanding of the effects of race on heart disease...
Iron deficiency in kidney disease patients on dialysis treated with investigational drug
11/12/2013
Doctors at the North Shore-LIJ Health System presented late-breaking data showing that an investigational drug Triferic is well tolerated and effective in treating iron deficiency in patients with chronic kidney disease undergoing dialysis. This data was presented at the American Society of Nephrology's Kidney Week 2013 in Atlanta, GA...