Inhibition of antioxidants may be a viable chemotherapeutic option for lung cancer
12/03/2013
Many cancers have adapted to cope with high levels of immune system-produced free radicals, also referred to as reactive oxygen species, by overproducing antioxidant proteins. One of these proteins, superoxide dismutase 1 (SOD1), is overproduced in lung adenocarcinomas and has been implicated as a target for chemotherapy.
Persistent global burden of anemia among young children and women
12/03/2013
Despite increasing efforts to diagnose and treat anemia worldwide, there remains a surprisingly large global burden of the disease, particularly among young children and women, according to a new report on trends in anemia between 1990 and 2010. The report* was published online in Blood, the Journal of the American Society of Hematology.
Tighter transfusion strategy recommended to treat anemia in patients with heart disease
12/03/2013
Red blood cell (RBC) transfusions should be restricted to those individuals with severe anemia in patients with heart disease, the American College of Physicians (ACP) recommends in a new clinical practice guideline published in Annals of Internal Medicine, ACP's flagship journal.
Targeting colon cancer stem cells show clinical potential
12/03/2013
Scientists and surgeons at Princess Margaret Cancer Centre have discovered a promising new approach to treating colorectal cancer by disarming the gene that drives self-renewal in stem cells that are the root cause of disease, resistance to treatment and relapse. Colorectal cancer is the third leading cause of cancer-related death in the Western world.
Scientists describe new proteins linked to cancer
12/03/2013
A newly defined family of proteins has been analyzed by researchers, who say its control over another class of proteins involved in cell division - CAAX proteins - could have major implications for cancer research. Results of their findings were recently published in the journal Nature.
Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA), according to new research publishing in Nature Communications. The research suggests that a protein strongly implicated in human cancer also governs the non-protein-coding genome.
Growth and spread of breast cancer may be fueled by high cholesterol
12/03/2013
A byproduct of cholesterol functions like the hormone estrogen to fuel the growth and spread of the most common types of breast cancers, researchers at the Duke Cancer Institute report.The researchers also found that anti-cholesterol drugs such as statins appear to diminish the effect of this estrogen-like molecule.
Degenerative tendon disease in athletes improved by PRP therapy
12/03/2013
Ultrasound-guided delivery of platelet-rich plasma (PRP) improves functionality and reduces recovery time in athletes with degenerative disease in their tendons, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).
New colorectal cancer target found in stem cell gene
12/02/2013
Researchers in Canada found that switching off a gene in the cancer stem cells that drive colon cancer stops them from being able to renew themselves. They say their study offers a starting point to treatments that could shut the cancer down.Cancer stem cells are cells that have the ability to differentiate into all the types of cell that exist in that type of tumor.
Angiogenesis and cancer growth controlled by methylation signaling
12/02/2013
A study led by researchers at Boston University School of Medicine (BUSM) demonstrates a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth. The findings are published in the December issue of Science Signaling.