How DNA damage affects Golgi - the cell's shipping department
2/03/2014
In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by DNA damage, with important consequences for the body's cellular response to chemotherapy.
Virus engineered to attack triple negative breast cancer cells
2/03/2014
Scientists have discovered a potential cure for one of the most aggressive and least treatable forms of breast cancer called "triple negative breast cancer." In laboratory experiments involving human cancer cells, scientists used a virus similar to the one that helped eradicate smallpox to coax cancer cells to produce a protein which makes them susceptible to radioactive iodine.
Agent Orange exposure increases skin cancer risk in Vietnam veterans
2/02/2014
The Vietnam War ended in 1975, but - even 4 decades later - high rates of non-melanoma invasive skin cancer are reported in Vietnam veterans exposed to the controversial herbicide Agent Orange, according to a new study published in the journal Plastic and Reconstructive Surgery.
For those who think that space exploration offers no tangible benefits for those of us on earth, a new research discovery involving thyroid cancer may prove otherwise. In a new report appearing in the February 2014 issue of The FASEB Journal, researchers from Germany and Denmark show that some tumors which are aggressive on earth are considerably less aggressive in microgravity.
Addressing cancer and health disparity issues: University of Maryland study
2/01/2014
Robust partnerships between rural community health education centers and academic health care institutions can make substantial strides toward addressing race-, income- and geographically-based health disparities in underserved communities by empowering both the community and leading University institutions, according to newly published research from the University of Maryland School of Medicine.
Screening for transformed human mesenchymal stromal cells with tumorigenic potential
2/01/2014
Researchers at Erasmus University Medical Center Rotterdam, The Netherlands, led by Dr. Qiuwei Pan and Dr. Luc van der Laan, have discovered that spontaneous tumorigenic transformation of human mesenchymal stem/stromal cells (MSCs) can occur during cell culture expansion, although the frequency is relatively low and often only observed after extensive passage in culture.
Molecular keys uncovered to invasive bladder cancer
2/01/2014
The once sketchy landscape of the molecular defects behind bladder cancer now resembles a road map to new, targeted treatments thanks to the unified efforts of scientists and physicians at 40 institutions.Deep molecular analysis of 131 muscle-invasive bladder cancer tumors found recurring defects in 32 genes for the cancer that currently has no targeted therapies.
Common cell-cycle biomarkers in both lung and bladder cancers
2/01/2014
A University of Colorado Cancer Center study published in the journal PLoS ONE shows that bladder and lung cancers are marked by shared differences in the genetics that control the cell cycle. Measuring these genetic signatures could allow doctors to refine a patient's prognosis, choose appropriate treatments, and perhaps offer new treatments that target these shared genetic abnormalities.
Long-term (five-year) outcomes of breast cancer patients receiving adjuvant accelerated partial breast irradiation (APBI) after breast-conserving surgery show excellent tumor control and breast cosmesis (cosmetic outcomes) with minimal late toxicity, according to a study published in the February 1, 2014 print edition of the International Journal of Radiation Oncology - Biology - Physics (Red...
Standard external beam radiation therapy (EBRT) provided a higher breast preservation rate than brachytherapy in women age 66 and older with invasive breast cancer, according to a study published in the February 1, 2014 print edition of the International Journal of Radiation Oncology - Biology - Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology...