Researchers bring scientific knowledge and health prevention habits closer to citizens
2/12/2014
As part of a civic science initiative, a group of researchers form the National Institute of Respiratory Diseases (INER) in collaboration with the Mexican Autonomous Technological Institute (ITAM), the National Institute of Carcinology (INCan) and the Philosophical Research Institute at the National Autonomous Mexican University (UNAM); with the support of the Science and Technology National...
How blood cancer's growth fueled in acute myelogenous leukemia
2/12/2014
Reinforcing the need to look beyond genomic alterations to understand the complexity of cancer, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote progression of the disease.
Acidic tumour pH inhibits chloroquine drug effect
2/12/2014
Low pH in tumours counteracts the desired effect of the drug chloroquine, according to a new study from Karolinska Institutet. The results, which are published in the scientific journal Autophagy, might explain possible lack of efficacy of chloroquine in clinical studies.Chloroquine, a widely used antimalaria drug, is currently under investigation in clinical trials on cancer patients.
An EORTC analysis appearing in Annals of Oncology confirmed the importance of known prognostic factors such as performance status and tumor grading for having a long-term outcome in patients treated with pazopanib for metastatic soft tissue sarcoma. Additionally, hemoglobin at baseline was found to be a new prognostic factor.
Unexpected cell hijack method in pancreatic cancer revealed by study
2/12/2014
Pancreatic stellate cells, which normally aid tissue repair, unwittingly help pancreatic cancer grow and spread in a method of 'cell hijack' only seen before in brain and breast cancer, according to new research from Queen Mary University of London.
Possible genetic markers found in breast cancer that spreads to the brain
2/12/2014
The Translational Genomics Research Institute (TGen) has uncovered possible genetic origins of breast cancer that spreads to the brain, according to a first-of-its-kind study published in the scientific journal PLOS ONE.
Fungal disease attacked by breast cancer drug
2/12/2014
Tamoxifen, a drug currently used to treat breast cancer, also kills a fungus that causes a deadly brain infection in immunocompromised patients. The findings, which could lead to new treatments for a disease that kills more HIV/AIDS patients than tuberculosis, appear in mBio®, the online open-access journal of the American Society for Microbiology (ASM.
How blood cancer's growth fueled in acute myelogenous leukemia
2/12/2014
Reinforcing the need to look beyond genomic alterations to understand the complexity of cancer, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote progression of the disease.
For women with BRCA gene mutation, 'double mastectomy better'
2/12/2014
Women with early-stage breast cancer who have a mutation in the BRCA gene are much less likely to die from the disease if they have a double mastectomy, compared with women who have the mutation and only have one breast removed. This is according to a study published in the BMJ.The research team, including Prof.
NYU Langone Medical Center researchers have found a biological weakness in the workings of the most commonly mutated gene involved in human cancers, known as mutant K-Ras, which they say can be exploited by drug chemotherapies to thwart tumor growth.