Biomarker- and receptor-targeted therapies in NSCLC influence clinical trial success
2/18/2014
Over the past decade, a great clinical focus has been directed at developing new and innovative therapies for advanced non-small cell lung cancer (NSCLC). An analysis of clinical trials evaluating these therapies demonstrates that the cumulative success rate for new agents for advanced NSCLC is lower than the industry-estimated rate.
High frequency of EGFR mutations found in Asian population
2/18/2014
Adenocarcinoma histology, female sex, never-smoking status, and Asian ethnicity have been considered the most important factors associated with EGFR mutations in non-small cell lung cancer and response to EGFR inhibitors.
To ensure correct number of chromosomes, epigenetic regulation essential
2/18/2014
Abnormal number of chromosomes is often associated with cancer development. In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.
'Moving' pediatric brain tumors by hijacking cancer migration mechanism
2/18/2014
One factor that makes glioblastoma cancers so difficult to treat is that malignant cells from the tumors spread throughout the brain by following nerve fibers and blood vessels to invade new locations. Now, researchers have learned to hijack this migratory mechanism, turning it against the cancer by using a film of nanofibers thinner than human hair to lure tumor cells away.
Improvements in colon cancer survival largely reflect gains among non-elderly whites and Asians
2/18/2014
While new and better treatments have improved the odds of survival for patients diagnosed with late stage colorectal cancer, that progress has been largely confined to non-Hispanic whites and Asians and those under age 65, according to a new study. American Cancer Society researchers led by Helmneh Sineshaw, M.D.
Mobile compression device recommended to prevent blood clots after joint surgery
2/18/2014
Research from The Shiley Center for Orthopaedic Research and Education at Scripps Clinic could change how patients are treated to prevent blood clots after joint replacement surgery.
Biomarker- and receptor-targeted therapies in NSCLC influence clinical trial success
2/18/2014
Over the past decade, a great clinical focus has been directed at developing new and innovative therapies for advanced non-small cell lung cancer (NSCLC). An analysis of clinical trials evaluating these therapies demonstrates that the cumulative success rate for new agents for advanced NSCLC is lower than the industry-estimated rate.
High frequency of EGFR mutations found in Asian population
2/18/2014
Adenocarcinoma histology, female sex, never-smoking status, and Asian ethnicity have been considered the most important factors associated with EGFR mutations in non-small cell lung cancer and response to EGFR inhibitors.
Improvements in colon cancer survival largely reflect gains among non-elderly whites and Asians
2/18/2014
While new and better treatments have improved the odds of survival for patients diagnosed with late stage colorectal cancer, that progress has been largely confined to non-Hispanic whites and Asians and those under age 65, according to a new study. American Cancer Society researchers led by Helmneh Sineshaw, M.D.
Mobile compression device recommended to prevent blood clots after joint surgery
2/18/2014
Research from The Shiley Center for Orthopaedic Research and Education at Scripps Clinic could change how patients are treated to prevent blood clots after joint replacement surgery.