First demonstration of anti-cancer activity for AG-120, an inhibitor of the IDH1 mutation, in patients with advanced leukaemia
11/19/2014

A phase I trial of the first drug designed to inhibit the cancer-causing activity of a mutated enzyme known as isocitrate dehydrogenase (IDH) 1, which is involved in cell metabolism, has shown...

Childhood central nervous system cancer affects identity in adulthood
11/19/2014

Patients who have been treated for cancer of the central nervous system (brain tumours) in childhood or adolescence can show affected self-perception and self-identity in adulthood.

News from Annals of Internal Medicine Supplement Nov. 18 2014
11/19/2014

1. Recommending MyFitnessPal to obese patients unlikely to produce weight lossUsing a smartphone app is unlikely to produce substantial weight loss for most overweight patients, according to an...

Researchers discover new way to fight chronic myeloid leukemia
11/19/2014

Chronic myeloid leukemia develops when a gene mutates and causes an enzyme to become hyperactive, causing blood-forming stem cells in the bone marrow to grow rapidly into abnormal cells.

Chemistry trick may herald transformational next-generation RNAi therapeutics aimed at cancer, viral infections and more
11/19/2014

Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses.

Novel delivery platform identified that leads to the inhibition of microRNA activity - and the control of cancer growth
11/19/2014

Since the discovery that microRNAs play key roles in regulating human disease, the hope has been that these short non-coding RNA molecules could be translated into a therapeutic strategy for the...

DAPT study favored 30 over 12 months of DAPT for lower clot and heart attack risk
11/19/2014

The Harvard Clinical Research Institute (HCRI) has announced results of the DAPT Study, a major international study that investigated the duration of dual antiplatelet therapy (DAPT, the combination...

Genetically low vitamin D levels linked to all-cause mortality
11/19/2014

People with genetically low concentrations of vitamin D may be at increased risk of all-cause mortality, but not cardiovascular mortality, according to a new study.

Hand soap antimicrobial linked to cancer and liver fibrosis
11/18/2014

Researchers say an agent found in shampoo, hand soap and other personal hygiene products - triclosan - caused liver fibrosis and cancer in mice, and it could pose a risk to humans.

New technology can detect bacterial invaders with unprecedented speed, sensitivity
11/18/2014

A new bloodstream infection test created by UC Irvine researchers can speed up diagnosis times with unprecedented accuracy, allowing physicians to treat patients with potentially deadly ailments more...