A multicenter phase 1 trial of the immune checkpoint blocker ipilimumab found clinical benefit in nearly half of blood cancer patients who had relapsed following allogeneic stem cell transplantation...
Agent THZ1 causes small cell lung tumors to shrink in pre-clinical testing
12/11/2014
Small cell lung cancer - a disease for which no new drugs have been approved for many years - has shown itself vulnerable to an agent that disables part of tumor cells' basic survival machinery...
Potential to predict which patients are at risk of developing therapy-related acute myeloid leukemia
12/11/2014
For a small percentage of cancer patients, treatment aimed at curing the disease leads to a form of leukemia with a poor prognosis.
A defining characteristic of cancer is disorder in the gene-control system
12/11/2014
The genetic tumult within cancerous tumors is more than matched by the disorder in one of the mechanisms for switching cells' genes on and off, scientists at Dana-Farber Cancer Institute and the...
New technology can improve sickle cell disease outcomes
12/11/2014
Researchers from Seidman Cancer Center at University Hospitals (UH) Case Medical Center and Case Western Reserve University School of Medicine presented new research findings at the 56th Annual...
Sleeping Beauty gene study shows encouraging results in patients with lymphoid malignancies
12/11/2014
Study results of CD19-directed chimeric antigen receptor (CAR) therapy using the Sleeping Beauty non-viral transduction system to modify T cells has demonstrated further promise in patients with...
Patients who relapse in their battle with acute myeloid leukemia (AML) may benefit from a phase three study of therapies that combine an existing agent, cytarabine, with a newer compound, vosaroxin.
Comparison of blood clot treatments illuminate recurrence risk in high-risk groups
12/11/2014
Studies presented at the 56th American Society of Hematology (ASH) Annual Meeting and Exposition compare new and standard-of-care treatments for blood clots and further illuminate clot risks in...
Following the movements in blood vessel tissue before, during and after cell division
12/11/2014
Nature's ingenious systems: A layer of cells called endothelial cells lines the interior of blood vessels. When blood flows through the vessels, such cells only divide to replace dead cells.
Shorter radiation treatment not given to most breast cancer patients
12/10/2014
Despite 2011 guidelines endorsing shorter radiation for early-stage breast cancer patients, a new study finds most eligible patients are still receiving a longer treatment.