New Points Of Attack On Breast Cancers Not Fueled By Estrogen
7/12/2011
Although it sounds like a case of gender confusion on a molecular scale, the male hormone androgen spurs the growth of some breast tumors in women. In a new study, scientists at Dana-Farber Cancer Institute provide the first details of the cancer cell machinery that carries out the hormone's relentless growth orders...
Fibrin, A Product Of The Blood Clotting Process, Is Key To Protection During Gram-Negative Sepsis
7/12/2011
New research from the Trudeau Institute may help to explain why anticoagulant therapies have largely failed to extend the lives of patients with sepsis. The study was led by Deyan Luo, a postdoctoral fellow in Stephen Smiley's laboratory...
Project Achilles Pinpoints Vulnerabilities In Ovarian Cancer
7/12/2011
Cancer is not invincible but its weaknesses can be difficult to detect. An effort known as Project Achilles named after the Greek warrior whose one vulnerability led to his undoing was launched to develop a systematic way of pinpointing these weak spots...
Guidelines For Alcohol Consumption Are Inadequate For Cancer Prevention
7/12/2011
Current alcohol consumption guidelines are inadequate for the prevention of cancer and new international guidelines are needed, states an analysis in CMAJ (Canadian Medical Association Journal). Guidelines in some countries are not currently based on evidence for long-term harm...
A Possible Stepping Stone From Environmental Chemical To Cancer
7/12/2011
Several chemicals that can accumulate to high levels in our body (for example BPA and some pesticides) have been recently linked to an increased risk of cancer and/or impaired responsiveness to anticancer drugs...
News From The Journal Of Clinical Investigation: July 11, 2011
7/12/2011
METABOLIC DISEASE: Sex hormone protection from type 2 diabetes The incidence of obesity and its common complication, type 2 diabetes, is approaching epidemic proportions in the developed world. A key event in the development of type 2 diabetes is the failure of beta-cells in the pancreas to produce enough of the hormone insulin to meet the body's demands...
Researchers Identify Key Role Of MicroRNAs In Melanoma Metastasis
7/12/2011
Researchers at the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, identified for the first time the key role specific microRNAs (miRNAs) play in melanoma metastasis to simultaneously cause cancer cells to invade and immunosuppress the human body's ability to fight abnormal cells. The new study is published in the July 11, 2011 issue of the journal Cancer Cell...
Epigenetic Pathway And New Drug Show Promise In Reversing A Hard-To-Treat Childhood Cancer
7/12/2011
A difficult-to-treat form of childhood leukemia relies on changes in the structure of DNA so-called epigenetic changes to wreak genomic havoc within white blood cells, according to one of two studies conducted by a research team at Children's Hospital Boston and Dana-Farber Cancer Institute...
APP Pharmaceuticals Announces Approval And Launch Of Clonidine Hydrochloride Injection
7/12/2011
APP Pharmaceuticals, Inc., a wholly owned subsidiary of Fresenius Kabi Pharmaceuticals Holding, Inc., announced today that it has received approval from the U.S. Food and Drug Administration (FDA) to market Clonidine Hydrochloride Injection in two dosage strengths...
Sunshine Biopharma Inc. (OTCBB: SBFM), a development stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed a detailed cytotoxicity study of its lead compound, Adva-27a, in MCF-7/MDR, a Multidrug Resistant Breast Cancer cell line...