More Clues To Causes Of Breast Cancer Revealed By Moffitt Cancer Center Researchers
10/31/2011
Publishing in the current issue of The Journal of Biological Chemistry (Vol. 286, No 43), researchers at Moffitt Cancer Center in Tampa, Fla., have discovered additional mechanisms of "Akt" activation and suggest a component of that activation mechanism - inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) - could be targeted as a therapeutic intervention for treating cancer...
Fat Cells In Abdomen Fuel Spread Of Ovarian Cancer
10/31/2011
A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011...
Consortium Gets $7.2 M Contract Renewal To Promote Phase II Clinical Trials
10/31/2011
The National Cancer Institute recently awarded $7.2 million for the competitive renewal of the Southeast Phase 2 Consortium (SEP2C), led by Moffitt Cancer Center's Daniel Sullivan, M.D., executive vice president and associate center director for Clinical Investigations. The renewal is through September 2016...
Glitazone Pretreatment Can Boost Efficacy Of Radioiodine Therapy In Metastatic Thyroid Cancer
10/31/2011
Repeated radio-ablation therapy with iodine-131 to treat metastatic thyroid cancer can be less effective than the initial round of treatment due to de-differentiation of the cancer cells as the disease progresses, making them less sensitive to I-131. Glitazones, a class of PPARg drugs capable of re-differentiating the cancer cells, can enhance their I-131 uptake...
Key Driver Of Metastasis Identified
10/31/2011
Scientists at Dalhousie University in Nova Scotia have identified a key mechanism of metastasis that could lead to blocking tumor growth if their findings are confirmed. In a recent issue of Cancer Research, a journal of the American Association for Cancer Research, lead researcher David Waisman, Ph.D...
Halting Cancer Growth By Controlling Gene Expression
10/31/2011
NUT midline carcinoma (NMC) is a cancer without a cure, and one that affects all age groups. NMC is a rapid-growth disease with an average survival time of four and a half months after diagnosis, making the development of clinical trials for potential therapies or cures for this cancer difficult, to say the least...
The Complex Signaling That Helps Cells Know When To Grow, When Not To
10/31/2011
Even yeast understand austerity. A finely tuned system evolved early on to help cells survive in a world where good times come as fast as they go. The system, a molecular switch found in organisms from yeast to humans, involves a nutrient-sensing protein that turns growth on in times of plenty and shuts it off when times are lean...
More Clues To Causes Of Breast Cancer Revealed By Moffitt Cancer Center Researchers
10/31/2011
Publishing in the current issue of The Journal of Biological Chemistry (Vol. 286, No 43), researchers at Moffitt Cancer Center in Tampa, Fla., have discovered additional mechanisms of "Akt" activation and suggest a component of that activation mechanism - inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) - could be targeted as a therapeutic intervention for treating cancer...
Fukushima Radiation Fallout Bigger Than Officially Reported
10/31/2011
Two reports released this month, one focusing on the marine, and the other on the atmospheric impact, find that the radiation fallout from the Fukushima Daiichi Nuclear Power Plant accident following the earthquake and tsunami in March is bigger than that reported by the Japanese government and electrical power company...
Measuring Quality Of Life Important In Cancer Survival Research
10/31/2011
Cancer survival studies should treat questions about how well people are surviving with the same importance as how long: putting quality of life on an equal footing with survival years, say researchers writing in a scientific journal this month...