Taxanes are a family of compounds that includes one of the most important cancer drugs ever discovered, Taxol®, among other cancer treatments. But the difficulty producing these complex molecules in the lab has hampered or blocked exploration of the family for further drug leads...
Research led by St. Jude Children's Research Hospital scientists has identified an unexpected mechanism facilitating some protein interactions that are the workhorses of cells and, in the process, identified a potential new cancer drug development target. The discovery involves a chemical known as an acetyl group...
Genes Identified That May Signal Long Life In Naked Mole-Rats
11/07/2011
Scientists at the University of Liverpool have identified high levels of a number of genes in the naked mole-rat that may suggest why they live longer than other rodents and demonstrate resistance to age-related diseases...
Canine Cancer-Chromosomal "Breakpoints" Link
11/07/2011
North Carolina State University researchers have uncovered evidence that evolutionary "breakpoints" on canine chromosomes are also associated with canine cancer. Mapping these "fragile" regions in dogs may also have implications for the discovery and treatment of human cancers. When new species evolve, they leave genetic evidence behind in the form of "breakpoint regions...
Mechanism Discovered In Brain Cancer Responsible For Neuron Death
11/06/2011
Researchers from Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine have discovered a mechanism by which glioblastoma multiforme (GBM), the most common form of brain cancer, promotes the loss of function or death of neurons, a process known as neurodegeneration...
Scientists at the Gladstone Institutes have identified a protein that kick-starts the response to low levels of oxygen, suggesting new lines of research relevant to a variety of potentially fatal disorders associated with diminished oxygen supply, including cancer, heart disease, stroke and other neurological conditions that affect millions of people worldwide...
Association Of Alcohol With Risk Of Breast Cancer: New Analysis From The Nurses' Health Study
11/06/2011
A well-done analysis by Chen WY et al, published in JAMA assesses the association of moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. The authors use prospectively collected data from the 105,986 women enrolled in the Nurses' Health Study followed up from 1980 until 2008 with an early adult alcohol assessment and 8 follow ups...
Rosetta Genomics, Ltd...
Albert Einstein College Of Medicine Receives $8 Million From NIH To Study How Cancer Spreads
11/05/2011
The National Cancer Institute (NCI) has awarded Albert Einstein College of Medicine of Yeshiva University two grants totaling $8 million to study the microenvironments that drive the spread of cancer from the primary tumor to other parts of the body in the process known as metastasis...
It has long been known that cancer cells use nutrients differently than normal cells. In recent years, the rapidly reemerging field of cancer metabolism has shed new light on the ways that cancers use glucose to grow and thrive, demonstrating that manipulation of an enzyme called PKM2 is important to this metabolic process...