"If Hamlet Give The First Or Second Hit", The Development Of Burkitt's Lymphoma
11/09/2011
Although Burkitt's lymphoma is thankfully fairly rare in the general population, it is the most common form of malignancy in children in Equatorial Africa and is very frequent in immunocompromised persons, such as those suffering from AIDS. It is invariably accompanied by an increase in the expression of a particular gene, the so-called c-myc gene...
Teaching Hospitals Best For Prostate Cancer Surgery
11/09/2011
Prostate cancer patients who undergo radical prostatectomy get better results at teaching hospitals than at non-academic medical institutions, according to the findings of an international study led by researchers at Henry Ford Hospital...
Advanced Liver Cancer - Experimental Drug Has Survival Benefits
11/08/2011
According to an announcement made by Transgene and Jennerex, Inc. the final data from a randomized dose-ranging Phase 2 clinical trial of JX594/TG6006 in 30 patients from sites in the U.S., Canada and South Korea with advanced liver cancer demonstrated a statistically important benefit in overall survival for patients receiving high doses of JX594/TG6006 compared to those receiving low doses...
Metastatic Breast And Ovarian Cancer Vaccine - Promising Results
11/08/2011
A trial published in Clinical Cancer Research demonstrated a positive response in both metastatic breast cancer and ovarian cancer to a recombinant poxviral vaccine. Lead investigator James Gulley, M.D., Ph.D...
News From The Journal Of Clinical Investigation: Nov. 7, 2011
11/08/2011
ONCOLOGY: Stopping breast cancer spread Most people who die from breast cancer do not die as a result of their breast tumor but because their cancer has spread (metastasized) to other parts of their body, often their lungs or bones...
Low Rates Of Breast Reconstruction After Mastectomy In Canada
11/08/2011
Few patients in Canada undergo breast reconstruction after mastectomy, despite its safety as a procedure and the positive psychological benefits, states a review article in CMAJ (Canadian Medical Association Journal). The article reviews rates of breast reconstruction and factors that influence the practice of immediate reconstruction in patients with early stage breast cancer...
Cancer-Causing Protein Strongly Tied To Hormone Resistance In Breast Cancer
11/08/2011
In dozens of experiments in mice and in human cancer cells, a team of Johns Hopkins scientists has closely tied production of a cancer-causing protein called TWIST to the development of estrogen resistance in women with breast cancer...
Erbitux (Cetuximab) Approved For Metastatic Head And Neck Cancer, USA
11/08/2011
Erbitux (cetuximab) has been approved by the US FDA for combination use with chemotherapy for late-stage head and neck cancer treatment. When given together with chemotherapy, Erbitus was found to extend the lives of patients compared to those on chemotherapy alone...
Some Colon Tumors Caused By Common Bacteria Altering Peroxide-Producing Gene
11/08/2011
Working with lab cultures and mice, Johns Hopkins scientists have found that a strain of the common gut pathogen Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO) in the intestine...
The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. Now, a team led by researchers at the University of Texas MD Anderson Cancer Center reports in advance online publication of the journal Nature that PKM2 has important non-metabolic functions in cancer formation...