Neurotransmitter Might Improve The Treatment Of Cancer
12/06/2011
Doses of a neurotransmitter might offer a way to boost the effectiveness of anticancer drugs and radiation therapy, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute...
Ovarian Cancer Outcome Can Be Predicted By Tiny Genetic Variation
12/06/2011
Yale Cancer Center researchers have shown that a tiny genetic variation predicts chances of survival and response to treatment for patients with ovarian cancer. The findings, published in the journal Oncogene, provide new insights into the biology of a new class of cancer marker and suggest a genetic test may help guide the treatment of women with ovarian cancer...
'Encouraging' Skin Cancer Discovery
12/06/2011
SCIENTISTS in Glasgow have made an important discovery in the fight against malignant melanoma, the most dangerous form of skin cancer. Unlike most other cancers, malignant melanoma is disproportionately higher in younger people than in other age groups. More than two young adults (aged 15-34) in the UK are diagnosed with the disease every day...
Making The 'Undruggable' Ras Oncogene 'Druggable'
12/06/2011
A drug discovery team at Genentech, Inc., has uncovered a chink in the molecular armor of Ras, the most commonly occurring oncogene, which is a gene that when mutated has the potential of causing cancer in humans...
New Reprogramming Mechanism For Tumor Cells Discovered
12/06/2011
A study by researchers Raul Mendez, ICREA Research Professor at the Institute for Research in Biomedicine (IRB Barcelona) and Pilar Navarro at the IMIM (Institut de Recerca Hospital del Mar, Barcelona) describes a new reprogramming mechanism for the expression of genes responsible for turning a healthy cell into a tumor cell...
Study Results On Frequent Mutation Of Genes Encoding UMPP Components In Kidney Cancer
12/06/2011
BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published online in Nature Genetics. In addition to BGI, co-leaders of the study included Peking University Shenzhen Hospital, Shenzhen Second People's Hospital, among others...
Gender Disparity In Skin-Cancer Rate May Be Explained By Antioxidant Levels
12/05/2011
Men are three times more likely than women to develop a common form of skin cancer but medical science doesn't know why. A new study may provide part of the answer. Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J...
Inflammatory Cues Modulate Goblet Cell Products Important For Intestinal Barrier Function
12/05/2011
In a paper published in the December 2011 issue of Experimental Biology and Medicine, a team of scientists at the University of Illinois, Urbana-Champaign led by Rex Gaskins, PhD have demonstrated that both microbial and host inflammatory factors modulate sulfomucin production in a human cell line, LS174T, that models intestinal goblet cells...
JCI Online Early Table Of Contents: Dec. 1, 2011
12/05/2011
CARDIOLOGY: Unraveling the adverse effects of a blood pressure medication Drugs that block L-type Ca2+ channels (LTCCs) are widely used to treat high blood pressure and angina, chest pain caused by restriction of the blood flow to the heart. However, these drugs can have adverse effects in patients with heart failure...
Novel Drug That Makes Brain Tumors Glow Hot Pink Being Tested
12/05/2011
Just 24 hours after Lisa Rek sang at her niece's wedding, her husband Brad was driving her to a local hospital. "The pain got worse. When we got to the emergency room, I said to Brad 'something is just not right,'" Rek remembers...