New research led by the NCIC Clinical Trials Group (CTG) at Queen's University has proven patients with limited stage Hodgkin's lymphoma have a better chance of long-term survival if they undergo a standard chemotherapy regimen as opposed to radiation-based treatment...
A High Risk Of Recurrence In Some Older Acute-Leukemia Patients Signaled By Gene Mutation
12/14/2011
Older people with acute myeloid leukemia and normal looking chromosomes in their cancer cells have a higher risk of recurrence if they have mutations in a gene called ASXL1, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James)...
Chronic Lymphocytic Leukemia Patients May Benefit From Novel Export-Inhibitor
12/14/2011
An experimental drug that works by blocking the export of key control molecules from the nucleus of cancer cells shows promise as a treatment for chronic lymphocytic leukemia (CLL) and other incurable B-cell malignancies, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J...
Treatment Decisions In Chronic Lymphocytic Leukemia Aided By Massive DNA Search
12/14/2011
The most comprehensive search to date of DNA abnormalities in chronic lymphocytic leukemia (CLL) has unearthed several new altered genes that drive this common blood cancer, a finding that could potentially help doctors predict whether an individual patient's disease will progress rapidly or remain indolent for years, say scientists from Dana-Farber Cancer Institute and the Broad Institute...
Shedding Light On Lymphoma Evolution With The Help Of Two Sisters
12/14/2011
When a 41-year-old woman was diagnosed with chronic-phase chronic myeloid leukemia, she received a bone marrow transplant and subsequent leukocyte infusion from her sister. These treatments controlled her leukemia, but seven years later, both sisters developed follicular lymphoma...
A New Way To Target Cancer Through Manipulating A Master Switch Responsible For Cancer Cell Growth
12/14/2011
Scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. The findings, published in the journal Cancer Cell, reveal how cancer cells grow faster by producing their own blood vessels...
Myelofibrosis Symptoms Reduced By Ruxolinitib
12/14/2011
In a major advance in treatment, a multicenter study found that ruxolinitib did a better job than off-label chemotherapy drugs reducing the terrible symptoms associated with myelofibrosis, including pain, enlarged spleen, anemia, fever, chills, fatigue, and weight loss. The results were presented at the annual meeting of the American Society of Hematology and Oncology in San Diego...
How Lymphoma Evolves - A Study Of Two Sisters
12/13/2011
A 41-year-old woman with chronic-phase chronic myeloid leukemia received a bone marrow transplant and subsequent leukocyte infusion from her sister to control her leukemia, however seven years on, both sisters developed follicular lymphoma...
How Do BRCA1 Mutations Harm Breast Cells? Researchers Demonstrate
12/13/2011
Researchers at the Johns Hopkins Kimmel Cancer Center have demonstrated during their work with breast cells that breast cells become vulnerable to cancer if a single copy of the breast cancer gene BRCA1 is inactivated. It causes genetic instability in the cells through reducing their ability to repair DNA damage...
Cancer Vaccine Significantly Reduces Tumor Size
12/13/2011
An experimental cancer vaccine has been found to reduce tumor size by an average of 80%, researchers from the Mayo Clinic and the University of Georgia reported in Proceedings of the National Academy of Sciences...