Gene Fusion In Lung Cancer Afflicting Never-Smokers May Be Target For Therapy
1/03/2012
Smoking is a well-known risk factor for lung cancer, but nearly 25% of all lung cancer patients have never smoked. In a study published online in Genome Research (http://www.genome.org), researchers have identified a previously unknown gene fusion event that could explain a significant proportion of lung cancer cases in never-smokers, and might serve as a target for new therapies...
Previously Unconnected Molecular Networks Conspire To Promote Cancer
1/03/2012
An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The University of Texas MD Anderson Cancer Center reports today in Molecular Cell...
Enzyme That Flips Switch On Cells' Sugar Cravings Could Be Anti-Cancer Target
1/03/2012
Cancer cells tend to take up more glucose than healthy cells, and researchers are increasingly interested in exploiting this tendency with drugs that target cancer cells' altered metabolism. Cancer cells' sugar cravings arise partly because they turn off their mitochondria, power sources that burn glucose efficiently, in favor of a more inefficient mode of using glucose...
High-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT), for previously untreated patients with advanced follicular lymphoma (FL) does not improve overall survival compared with conventional-dose chemotherapy alone, according to an online study published December 21 in the Journal of the National Cancer Institute...
Positive Feedback And Tumorigenesis
1/02/2012
Cancer cells are essentially immortal. The acquisition of an unlimited capacity to divide - the process of immortalization - is a central event in the genesis of tumors. Normally, cells are subject to stringent mechanisms which control their proliferation. Together these ensure that pre-malignant cells are induced to enter a senescent, non-dividing state or to undergo apoptosis, i.e...
Gene Links Rare And Unrelated Cancers
1/02/2012
Scientists at the BC Cancer Agency, Vancouver Coastal Health Research Institute, and the University of British Columbia are excited over a discovery made while studying rare tumour types. Dr. David Huntsman, genetic pathologist and director of the Ovarian Cancer Program of BC at the BC Cancer Agency and Vancouver Coastal Health Research Institute and Dr...
Lung Cancer Alliance Calls 2011 "The Turning Point"
1/01/2012
Lung Cancer Alliance (LCA) President Laurie Fenton-Ambrose predicted that because of major breakthroughs this year in screening, treatment and research, 2011 will be defined as the turning point year for lung cancer...
Roswell Park Researcher Aims To Develop Screening Test For Lung Cancer
1/01/2012
Lung cancer takes a heavy toll, contributing to more cancer deaths in the United States each year than breast, prostate and colon cancers combined. Contributing to this poor prognosis is the fact that lung cancer often goes undetected until the disease has reached an advanced and more difficult-to-treat stage...
Ring In A New Healthier You In 2012
1/01/2012
With the start of a new year, Dana-Farber Cancer Institute experts are encouraging people to ring in new healthy habits and offer a number of free and low-cost strategies to help people maintain good health and possibly reduce various cancer risks. Get moving! Staying fit and healthy can be as simple as lacing up a pair of sneakers and going for a walk...
Jennerex, Inc., a private clinical-stage biotherapeutics company focused on the development and commercialization of first-in-class targeted oncolytic virus products for cancer, announced that the first patient has been treated in a Phase 2a clinical trial of JX-594 as a neoadjuvant therapy in patients who are undergoing surgery to treat colorectal cancer that has spread to the liver...