News From The Journal Of Clinical Investigation: Feb. 13, 2012
2/14/2012
METABOLIC DISEASE: A direct hit from the hormone leptin has potential therapeutic consequences The number of people who suffer from one or more of the adverse complications of obesity, including type 2 diabetes, is rapidly increasing. The hormone leptin decreases food intake and increases energy expenditure. As such, it was hoped that it could be developed as an anti-obesity agent...
Link Between NSAIDs And Reduced Cancer Metastasis Strengthened By Study
2/14/2012
A new study reveals key factors that promote the spread of cancer to lymph nodes and provides a mechanism that explains how a common over-the-counter anti-inflammatory medication can reduce the spread of tumor cells through the lymphatic system. The research, published by Cell Press in the February 14 issue of the journal Cancer Cell, opens new avenues for the design of antimetastatic therapies...
Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) developed a new mouse model for studying a devastating childhood brain cancer called medulloblastoma. The animal model mimics the deadliest of four subtypes of human medulloblastoma, a tumor that is triggered by elevated levels of a gene known as Myc...
Enhancing The Effectiveness Of A Breast Cancer Treatment
2/14/2012
Breast cancers expressing the protein HER2 have a particularly poor prognosis. Treatment with trastuzumab (Herceptin) benefits some patients with HER2-positive breast cancer, but it is not as effective as had been hoped. Researchers are therefore seeking ways to enhance the effectiveness of trastuzumab...
News From The Journal Of Clinical Investigation: Feb. 13, 2012
2/14/2012
METABOLIC DISEASE: A direct hit from the hormone leptin has potential therapeutic consequences The number of people who suffer from one or more of the adverse complications of obesity, including type 2 diabetes, is rapidly increasing. The hormone leptin decreases food intake and increases energy expenditure. As such, it was hoped that it could be developed as an anti-obesity agent...
Differences Between Primary And Recurrent Ovarian Cancers Revealed By Molecular Profiling
2/14/2012
There is a need to analyze tumor specimens at the time of ovarian cancer recurrence, according to a new study published in Molecular Cancer Therapeutics. Researchers used a diagnostic technology called molecular profiling to examine the differences in the molecular characteristics of primary and recurrent ovarian tumors and found significant changes for some biomarkers...
The Mobile Health Competition is now closed, but the journey is just beginning for the winning idea. Between 2006 and 2008, cancer affected approximately 2000 teenagers in the UK.1 These are people as young as 15 years old, battling and living with cancer, while going through one of the toughest periods in any person's life - the teenage years...
Discovery Of Complex Wiring Of Nervous System Provides Clues To Neurological Diseases And Cancer
2/14/2012
Researchers at the Salk Institute have discovered a startling feature of early brain development that helps to explain how complex neuron wiring patterns are programmed using just a handful of critical genes. The findings, published in Cell, may help scientists develop new therapies for neurological disorders, such as amyotrophic lateral sclerosis (ALS), and provide insight into certain cancers...
Platelet Rich Plasma Treatment Aids Healing Of Elbow Injuries Say Researchers
2/14/2012
As elbow injuries continue to rise, especially in pitchers, procedures to help treat and get players back in the game quickly have been difficult to come by. However, a newer treatment called platelet rich plasma (PRP) may pose hope, according to researchers presenting their findings at the American Orthopaedic Society for Sports Medicine's Specialty Day meeting in San Francisco...
Differences Between Primary And Recurrent Ovarian Cancers Revealed By Molecular Profiling
2/14/2012
There is a need to analyze tumor specimens at the time of ovarian cancer recurrence, according to a new study published in Molecular Cancer Therapeutics. Researchers used a diagnostic technology called molecular profiling to examine the differences in the molecular characteristics of primary and recurrent ovarian tumors and found significant changes for some biomarkers...