Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape...
Early Cancer Detection Via New Blood Test: Research In The Early Stages Of Clinical Trials
2/22/2012
A simple blood test is being developed by researchers at Ben-Gurion University of the Negev (BGU) and Soroka University Medical Center in Beer-Sheva, Israel that may provide early detection of many types of cancer. Prof. Kapelushnik of BGU's Faculty of Health Sciences and his team developed a device that illuminates cancer cells with less than a teaspoon of blood...
Identification Of 'Stealth' Properties Of Cancer-Causing Genetic Mutations
2/22/2012
Scientists have discovered that cancer-causing genetic mutations have better-disguised electronic signatures than other mutations - a trait which could help them fly under the radar of the body's defence mechanisms...
Possible New Target For Cancer Therapy - Energy Network Within Cells
2/22/2012
Mitochondria, tiny structures within each cell that regulate metabolism and energy use, may be a promising new target for cancer therapy, according to a new study. Manipulation of two biochemical signals that regulate the numbers of mitochondria in cells could shrink human lung cancers transplanted into mice, a team of Chicago researchers report in the journal FASEB...
Cancer Cells Destroyed By Blocking Telomerase But Resistance, Progression Provoked
2/22/2012
Inhibiting telomerase, an enzyme that rescues malignant cells from destruction by extending the protective caps on the ends of chromosomes, kills tumor cells but also triggers resistance pathways that allow cancer to survive and spread, scientists report in Cell...
Potential For Development Of Tailor-Made Anticancer Agents Following Mapping Of Protein Inhibitors
2/22/2012
A team of researchers at Karolinska Institutet has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism behind putative side effects of the so-called PARP inhibitors, and can play an important role in the development of novel tailor-made cancer drugs...
Reformulated Imatinib Eliminates Morphine Tolerance In Lab Studies
2/22/2012
By reformulating the common cancer drug imatinib (Gleevec®), researchers have eliminated morphine tolerance in rats - an important step toward improving the effectiveness of chronic pain management in patients, according to researchers at The University of Texas MD Anderson Cancer Center. Narcotics such as morphine are a mainstay of chronic pain treatment...
For Patients With Advanced Hepatitis C, The Benefits Of Treatment Outweigh The Costs
2/22/2012
A towering $60,000 bill, a year of fierce, flu-like symptoms and a running risk of depression are among the possible costs of two new hepatitis C treatments. But according to Stanford University health policy researchers, they might be worth it...
Prostate Cancer Progression Driven By Telomere Failure, Telomerase Activation
2/22/2012
Genomic instability caused by an erosion of the protective caps on chromosomes, followed by activation of an enzyme that reinforces those caps, allows malignant cells to evade destruction and acquire more deadly characteristics, researchers report in an Online Now article at the journal Cell...
Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape...