Protein Modified By Researchers May Reduce Heart Attack Damage
3/03/2012
Scientists modified a protein in the heart which dramatically reduced cell damage after heart attacks, according to new research published the American Heart Association journal Arteriosclerosis, Thrombosis and Vascular Biology. The modified protein reduced cell damage by 50 percent in mice without causing harmful inflammation, the researchers found...
News From The Journal Of Clinical Investigation: March 1, 2012
3/03/2012
ONCOLOGY: New insight into brain tumor aggressiveness Malignant gliomas are the most common and lethal of all human brain tumors that originate in the brain. Patients with malignant gliomas have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies...
Sensitizing Tumor Cells To Radiotherapy
3/03/2012
Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer worldwide. Tumor resistance to radio- and/or chemotherapy remains a significant clinical problem...
Protein Complex Affects Cells' Ability To Move, Respond To External Cues
3/03/2012
In a paper published today in the journal Cell, a team from the University of North Carolina at Chapel Hill has explained for the first time how a long-studied protein complex affects cell migration and how external cues affect cell's ability to migrate...
Potential New Therapeutic Target For A Subset Of Aggressive Breast Cancers
3/03/2012
The main cause of death in women with breast cancer is spread of the original tumor to distant sites, a process known as metastasis. New therapeutic targets are urgently needed...
Discovery Of 5 Novel Gene Mutations Linked To Platelet Counts In African Americans
3/03/2012
Researchers, led by scientists from Johns Hopkins, have found five previously unknown gene mutations believed to be associated with elevated blood platelet counts in African-Americans, findings they say could someday lead to the development of new drugs to help prevent coronary artery disease...
Potential New Therapeutic Target For A Subset Of Aggressive Breast Cancers
3/03/2012
The main cause of death in women with breast cancer is spread of the original tumor to distant sites, a process known as metastasis. New therapeutic targets are urgently needed...
Discovery Of 5 Novel Gene Mutations Linked To Platelet Counts In African Americans
3/03/2012
Researchers, led by scientists from Johns Hopkins, have found five previously unknown gene mutations believed to be associated with elevated blood platelet counts in African-Americans, findings they say could someday lead to the development of new drugs to help prevent coronary artery disease...
Vemurafenib, Doubles Survival Of Metastatic Melanoma Patients
3/02/2012
A report published this week in the New England Journal of Medicine shows that the 50 percent of metastatic melanoma patients with a specific genetic mutation benefit from the drug Vemurafenib - increasing median survival from about 6 months to 15.9 months. In patients who responded, the drug stopped cancer progression for a median 6.7 months...
How Red Blood Cells Get So Big - And The Bad Things That Happen When They Don't
3/02/2012
Yale researchers have discovered how megakaryocytes - giant blood cells that produce wound-healing platelets - manage to grow 10 to 15 times larger than other blood cells. The findings, to be published March 13 in the journal Developmental Cell, also hint at how a malfunction in this process may cause a form of leukemia...