Targeting Androgens In Prostate Cancer
6/22/2012
Prostate cancer cells require androgens including testosterone to grow. A recent review in the British Journal of Urology International describes new classes of drugs that target androgens in novel ways, providing alternatives to the traditional methods that frequently carry high side effects...
Carcinogens Linked To Cancer Stem Cells, But Spinach Can Help
6/22/2012
Researchers at Oregon State University have for the first time traced the actions of a known carcinogen in cooked meat to its complex biological effects on microRNA and cancer stem cells. The findings are part of a growing awareness of the role of epigenetics in cancer, or the ways in which gene expression and cell behavior can be changed even though DNA sequence information is unaltered...
New Prognosis Tool For Deadly Brain Cancer - Glioblastoma Multiforme
6/22/2012
A diagnosis of glioblastoma multiforme (GBM) is generally a death sentence, but new research from the University of Wisconsin-Madison lab of Dr. John Kuo shows that at least one subtype is associated with a longer life expectancy. This discovery could help with better patient prognoses and lead to targeted drug treatments for GBM subtypes...
Tissue Stiffness Research By Husband-Wife Research Team Aims To Improve Breast Cancer Exams
6/22/2012
One in eight women in the United States will develop breast cancer over the course of her lifetime. Lorraine G. Olson, professor of mechanical engineering at the Rose-Hulman Institute of Technology in Terre Haute, Indiana, was diagnosed in 2005 at the age of 45...
Biologists Find The Cause Of Pain In The Treatment Of Fair Skin Cancer
6/22/2012
Pain caused by 2 different mechanisms Apply the ointment, light on, light off - that's how easy it is to cure various forms of non-melanoma skin cancer. However, the majority of patients suffer severe pain during the so-called photodynamic therapy. Why the treatment with ointment and red light can be so painful has now been uncovered by researchers from the RUB...
HPV Vaccine Trial Should Never Have Been Run In India, Researchers Say
6/22/2012
Research published in the Journal of the Royal Society of Medicine raises further questions about a trial of HPV vaccines in India. The trial, which has now been halted and is the subject of an investigation by the Indian government, was examining the safety and feasibility of offering a vaccine against the virus associated with cervical cancer...
Potential Drug Targets In Common Childhood Brain Tumor Identified By Gene Sequencing Project
6/22/2012
Researchers studying the genetic roots of the most common malignant childhood brain tumor have discovered missteps in three of the four subtypes of the cancer that involve genes already targeted for drug development. The most significant gene alterations are linked to subtypes of medulloblastoma that currently have the best and worst prognosis...
New Genetic Alterations Discovered Through US-Mexico Sequence-Analysis Collaboration
6/22/2012
Breast cancer is not a single disease, but a collection of diseases with dozens of different mutations that crop up with varying frequency across different breast cancer subtypes. Deeper exploration of the genetic changes that drive breast cancer is revealing new complexity in the leading cause of cancer death in women worldwide...
New Blood Thinning Drugs Under The Microscope
6/22/2012
Scientists have examined strategies to reverse the effects of new blood thinning drugs, to stop dangerous bleeding in case of an accident or emergency surgery. Many people in the UK take blood thinning drugs to reduce their risk of stroke. In an emergency situation, where a patient is likely to bleed heavily, doctors need to reverse the blood thinning effects and encourage the blood to clot...
Revlimid (lenalidomide) Extension Of Indication Submission Withdrawn, Europe
6/21/2012
The European Medicines Agency has been informed by Celgene Europe Limited that it has withdrawn its submission for approval for Revlimid (lenalidomide) - an application for an extension of the therapeutic indication in newly diagnosed multiple myeloma (blood cancer) patients, as well as new pack sizes had been sought...