Risk For Testicular Cancer Increases With Genetic Copy-Number Variants
8/05/2012
Genetics clearly plays a role in cancer development and progression, but the reason that a certain mutation leads to one cancer and not another is less clear. Furthermore, no links have been found between any cancer and a type of genetic change called "copy-number variants," or CNVs...
Breast Cancer Slowed By Plant-Based Compound In Mouse Model
8/05/2012
The natural plant compound phenethyl isothiocyanate (PEITC) hinders the development of mammary tumors in a mouse model with similarities to human breast cancer progression, according to a study published in the Journal of the National Cancer Institute. Edible plants are gaining ground as chemopreventative agents...
Afinitor Approved In Europe For Advanced Breast Cancer
8/04/2012
E.U. approval has been granted to Novartis drug Afinitor® (everolimus) after successful completion of the Phase III BOLERO-2 (Breast cancer trials of OraL EveROlimus-2) trial...
How Protein Component That Enables Cell Replication Gets Ferried To Chromosome Tips
8/04/2012
Stem cells are special. Nestled in muscle and skin, organ and bone, they bide their time over years or decades until called to replace damaged or lost tissue. One secret to their longevity is an enzyme called telomerase, which stills the relentless ticking of the molecular clock that limits the life span of other cells...
Mechanism Of Lung Cancer-Associated Mutations Suggests New Therapeutic Approaches
8/03/2012
Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors...
Afinitor Approved In Europe For Advanced Breast Cancer
8/03/2012
E.U. approval has been granted to Novartis drug Afinitor® (everolimus) after successful completion of the Phase III BOLERO-2 (Breast cancer trials of OraL EveROlimus-2) trial...
News From The Journal Of Clinical Investigation: Aug. 1, 2012
8/03/2012
ONCOLOGY Chemokine pathway suppresses colon cancer metastasis Chemokines are signals in the body that act as beacons, calling out to migrating cells, such as white blood cells, guiding them to where they are needed...
Researchers at Mayo Clinic have completed the world's first genome-wide sequencing analysis of peripheral T-cell lymphomas, unlocking the genetic secrets of this poorly understood and highly aggressive cancer of the immune system. Andrew Feldman, M.D...
3 Related Studies Help Uncover The Rules Governing Gene Transcription
8/03/2012
A trio of groundbreaking publications from researchers in Northwestern University's Physical Sciences-Oncology Center (PS-OC) report important methodological advances that will enable a better understanding of how gene expression is regulated, both in normal cells and in cancer cells. This knowledge could lead to the development of more effective therapeutic agents to treat cancer patients...
Critical Molecular Switch Discovered That Regulates Autophagy
8/03/2012
The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer...