Sanford-Burnham researchers discover molecule that controls tumor vessel maturation -- a counterintuitive approach that could improve cancer drug delivery To survive, tumors need blood supply to provide them with nutrients and oxygen. To get that supply, cancer cells stimulate new blood vessel growth - a process called tumor angiogenesis...
News From The Journal Of Clinical Investigation: Aug. 13, 2012
8/14/2012
New class of proteins allows breast cancer cells to evade Tyrosine Kinase Inhibitors Aberrant regulation of cell growth pathways is required for normal cells to become cancerous, and in many types of cancer, cell growth is driven by a group of enzymes known as receptor tyrosine kinases (RTKs)...
New Therapy That Prevents Lung Cancer Growth In Mice
8/14/2012
The discovery, which is already being tested in co-clinical trials, brings new clues for the treatment of this disease Lung cancer is one of the most aggressive types of cancer and the most common cause of death from this disease worldwide...
Cathepsin Cannibalism
8/14/2012
Researchers for the first time have shown that members of a family of enzymes known as cathepsins - which are implicated in many disease processes - may attack one another instead of the bodily proteins they normally degrade. Dubbed "cathepsin cannibalism," the phenomenon may help explain problems with drugs that have been developed to inhibit the effects of these powerful proteases...
Cancer-Protective Effect Of Daily Aspirin Smaller Than Previously Thought
8/14/2012
A new study adds support to the idea that daily aspirin use results in fewer cancer deaths, but the effect may not be as large as previous research might suggest...
Killing Prostate Cancer Cells Without Harming Other Healthy Cells
8/14/2012
Experimenting with human prostate cancer cells and mice, cancer imaging experts at Johns Hopkins say they have developed a method for finding and killing malignant cells while sparing healthy ones. The method, called theranostic imaging, targets and tracks potent drug therapies directly and only to cancer cells...
Lymphedema Patients Require Individualized Care
8/14/2012
Millions of American cancer survivors experience chronic discomfort as a result of lymphedema, a common side effect of surgery and radiation therapy in which affected areas swell due to protein-rich fluid buildup...
Daily Aspirin May Decrease Cancer Mortality
8/14/2012
A large new observational study finds more evidence of an association between daily aspirin use and modestly lower cancer mortality, but suggests any reduction may be smaller than that observed in a recent analysis...
Cancer Mortality Rates May Be Lowered By Daily Aspirin Usage
8/13/2012
Researchers have discovered in a new study published in the August 10 edition of the Journal of the National Cancer Institute, that even though taking aspirin on a daily basis is linked to lower overall cancer mortality, this association may be smaller than previously thought...
Radiation Therapy After Lumpectomy Helps Prevent A Future Masectomy
8/13/2012
To avoid a future mastectomy, older women with early stage breast cancer may want to have radiation therapy following lumpectomy. Although this is contrary to clinical recommendations, a new study featured online in the journal CANCER revealed that current beliefs regarding risks and benefits of radiation for early stage breast cancer in older women might not be accurate...