News From The Annals Of Internal Medicine: Aug. 21, 2012
8/22/2012
1. Colonoscopy-related Factors More Important Than Polyp Characteristics for Predicting Colorectal Cancer Risk Published research suggests that colonoscopy saves lives through detection and removal of adenomas, or benign tumors. Patients who have adenomas removed during colonoscopy are at higher risk for recurring adenomas and colorectal cancer than those who have had a negative colonoscopy...
Stopping Life-Threatening Internal Bleeding
8/22/2012
Progress toward a new emergency treatment for internal bleeding - counterpart to the tourniquets, pressure bandages and Quick Clot products that keep people from bleeding to death from external wounds - was reported at the 244th National Meeting & Exposition of the American Chemical Society, the world's largest scientific society. Erin Lavik, Sc.D...
LPA1 Inhibition Induces Metastatic Dormancy In Mouse Models Of Breast Cancer
8/21/2012
A lysophosphatidic acid receptor 1 (LPAR1) inhibitor, known as Debio-0719, suppresses the development of metastases in mice by inducing cancer cell dormancy, according to a study published August 21 in the Journal of the National Cancer Institute. Metastasis is a main contributor to mortality in cancer patients...
Researchers Identified Markers That Predict Progression Of Oral Lesions To Cancer
8/21/2012
Patients with oral lesions can be grouped according to risk level A group of molecular markers have been identified that can help clinicians determine which patients with low-grade oral premalignant lesions are at high risk for progression to oral cancer, according to data from the Oral Cancer Prediction Longitudinal Study published in Cancer Prevention Research, a journal of ...
Drop In Circumcision Of Male Newborns Could Add Billions To Health Care Costs
8/21/2012
A team of disease experts and health economists at Johns Hopkins warns that steadily declining rates of U.S. infant male circumcision could add more than $4.4 billion in avoidable health care costs if rates over the next decade drop to levels now seen in Europe...
Drop In Circumcision Of Male Newborns Could Add Billions To Health Care Costs
8/21/2012
A team of disease experts and health economists at Johns Hopkins warns that steadily declining rates of U.S. infant male circumcision could add more than $4.4 billion in avoidable health care costs if rates over the next decade drop to levels now seen in Europe...
Common Antifungal Drug Shrinks Tumors
8/21/2012
An approved generic drug that has been in use for decades is showing promise as a treatment for cancer: in trials on mice it shrank tumors by disrupting their blood supply. Thiabendazole is a generic, FDA-approved, inexpensive antifungal and antihelmintic drug that can be taken orally and has been in clincal use for over 40 years. The drug is not currrently used to treat cancer...
Diagnosing Disease With The Help Of 'DNA Wires'
8/21/2012
In a discovery that defies the popular meaning of the word "wire," scientists have found that Mother Nature uses DNA as a wire to detect the constantly occurring genetic damage and mistakes that - if left unrepaired - can result in diseases like cancer and underpin the physical and mental decline of aging...
Studying How Elesclomol Works Reveals New Molecular Target For Melanoma Treatment
8/21/2012
A laboratory study led by UNC medical oncologist Stergios Moschos, MD, demonstrates how a new targeted drug, Elesclomol, blocks oxidative phosphorylation, which appears to play essential role in melanoma that has not been well-understood...
Mouse Study Finds Clear Linkages Between Inflammation, Bacterial Communities And Cancer
8/21/2012
What if a key factor ultimately behind a cancer was not a genetic defect but ecological? Ecologists have long known that when some major change disturbs an environment in some way, ecosystem structure is likely to change dramatically...