Body May Be Able To 'Coach' Transplanted Stem Cells To Differentiate Appropriately
11/21/2012
Pluripotent stem cells are nature's double-edged sword. Because they can develop into a dizzying variety of cell types and tissues, they are a potentially invaluable therapeutic resource. However, that same developmental flexibility can lead to dangerous tumors called teratomas if the stem cells begin to differentiate out of control in the body...
Researchers Excel In Predicting Cancer Drug Sensitivity In An International Crowdsourcing Challenge
11/21/2012
Researchers from Helsinki Institute for Information Technology HIIT and Institute for Molecular Medicine Finland FIMM have developed a triumphant solution for predicting responses of breast cancer cells to a set of cancer drugs. The prediction is based on the genomic profiles of the cancer cells...
Acute Myeloid Leukemia - A Code Of Silence
11/20/2012
The development of acute myeloid leukemia (AML) is associated with a variety of genetic changes. Some of these alterations are epigenetic, wherein the sequence of the genes is unchanged, but chemical modifications to the DNA alter gene expression...
UK Lung Cancer Patients' Lives At Risk Due To Lack Of Specialist Care Say Experts
11/20/2012
There are 'insufficient specialists' to serve the UK's multidisciplinary lung cancer teams (LCMDTs) - and some healthcare professionals still hold a 'pessimistic and outdated' view of what can be achieved for patients - says a new, national report published today (20 November) by leading lung cancer experts...
Adding Avastin to the current standard of care for newly diagnosed aggressive brain cancer (glioblastoma multiforme, GBM) can significantly extend the time people live without their disease worsening, by 4.4 months (progression free survival of 10.6 months compared to 6.2 months with radiation and chemotherapy plus placebo, HR =0 ...
Principles By Which CRC Mutations May Cause Cancer Revealed By DNA Packaging Discovery
11/20/2012
A new discovery from researchers at Huntsman Cancer Institute (HCI) at the University of Utah concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases. The discovery, by Bradley R...
Re-Thinking Cancer's Bad Guy
11/20/2012
Researchers at the University of Copenhagen have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain. These findings are the subject of a paper, published this week in Nature Communications.. They point the way to new avenues of research into degenerative brain diseases like Alzheimer's...
Clues To Cause Of Pediatric Brain Tumors
11/20/2012
Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children. In new research, scientists at Washington University School of Medicine in St. Louis have identified a cell growth pathway that is unusually active in pediatric brain tumors known as gliomas...
A Step Closer To Understanding The Cause Of Deadly Sepsis
11/20/2012
Following an infection, dysregulation of the immune system can result in a systemic inflammatory response and an often fatal condition called severe sepsis or septic shock. Sepsis is not uncommon, yet its cause and underlying immune dysfunction remain poorly understood...
Certain Jobs Associated With Higher Breast Cancer Risk
11/19/2012
Certain occupations lead to a higher risk of breast cancer than others, specifically ones that bring the worker in contact with possible carcinogens and endocrine disruptors. This previously ignored topic has been addressed in new research in the journal Environmental Health...