Stem Cells That Become Resistant To Leukemia Drug May Be Source Of Genetic Chaos
12/15/2012
An international team of scientists, led by researchers from Temple University School of Medicine, has found that a source of mounting genomic chaos, or instability, common to chronic myeloid leukemia (CML) may lie in a pool of leukemia stem cells that are immune to treatment with potent targeted anticancer drugs...
Research Uncovers Anti-Aging Gene As Tumor Suppressor In Mouse Model
12/15/2012
A new study sheds more light on how an anti-aging gene suppresses cancer growth, joint University of Michigan Health System and Harvard Medical School research shows. Loss of the SIRT6 protein in mice increases the number, size and aggressiveness of tumors, according to the new research published in the scientific journal Cell...
Genes Are Not The Only Drivers Of Colon Cancer
12/15/2012
Genes are not the only drivers of colon cancer. A new study suggests cellular factors play an equally important part, and these not only drive tumor growth, but also affect how well the disease responds to chemotherapy...
Roche's Breast Cancer Drug Perjeta Receives Green Light From EU
12/15/2012
Today, Roche declared that the European Union gave a positive recommendation for the use of Perjeta (pertuzumab) in combination with Herceptin (trastuzumab) and docetaxel in patients with HER2-positive metastatic or location specific recurrent breast cancer that cannot be removed with surgery...
HPV In Older Women May Be Due To Reactivation Of Virus, Not New Infection
12/15/2012
A new study suggests that human papillomavirus (HPV) infection in women at or after menopause may represent an infection acquired years ago, and that HPV infections may exist below limits of detection after one to two years, similar to other viruses, such as varicella zoster, which can cause shingles...
Hard-to-treat Myc-Driven Cancers May Be Susceptible To Drug Already Used In Clinic
12/14/2012
The mTORC1 inhibitor everolimus is used to treat various medical conditions. Everolimus prevented disease development in a mouse model of Myc-driven lymphoma. Treatment led to tumor regression in mice by inducing cellular senescence...
Pioneering Drug For Advanced Prostate Cancer Has Major Benefit For Earlier Disease Too
12/14/2012
A drug already set to transform care for men with advanced prostate cancer has impressive benefits for men with earlier-stage disease too, a major new clinical trial shows...
A potent chemotherapy agent wrapped within a monoclonal antibody selectively destroys the malignant cells responsible for acute lymphocytic leukemia (ALL) in either weekly or monthly dosing, researchers report at the 54th ASH Annual Meeting and Exposition...
Targeting The Specific Genetic Mutations That Cause Lung Cancer's Many Varieties
12/14/2012
A review in the December issue of the journal Archives of Pathology & Laboratory Medicine by Paul Bunn Jr, MD, University of Colorado Cancer Center investigator and past president of ASCO, IASLC and AACI describes the current state of lung cancer care...
Potential Gene Therapy Approach To Sickle Cell Disease
12/14/2012
Researchers at Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) have taken the first preliminary steps toward developing a form of gene therapy for sickle cell disease. In an abstract presented at the 54th annual meeting of the American Society of Hematology, the research team - led by DF/CHCC's Raffaele Renella, MD, PhD, Stuart H. Orkin, MD, and David A...