Potential Diagnostic Test For Genetic Predisposition To Abnormal Blood Clotting
2/06/2013
The non-O ABO blood type is the most important risk factor for venous thromboembolism (blood clots in veins), making up 20% of attributable risk for the condition, according to a new study in CMAJ (Canadian Medical Association Journal). This finding has implications for genetic screening for thrombophilia, a genetic predisposition to abnormal blood clotting...
1. Being Physically Fit Earlier in Life May Lower Risk for Dementia Later in Life Having a higher fitness level at midlife seems to be associated with lower hazards of developing Alzheimer disease and other types of dementia later in life...
In Men Receiving BMTs From Female Donors, Cells Predict Onset Of Graft-Versus-Host Disease
2/06/2013
Stanford University School of Medicine investigators have identified a clutch of cells that - if seen in a male patient's blood after receiving a brand-new immune system in the form of a bone-marrow transplant from a female donor - herald the onset of chronic graft-versus-host disease, or cGVHD...
Discovery Of Mutations Linked To Relapse Of Childhood Leukemia
2/06/2013
After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that lead to drug resistance and relapse in the most common type of childhood cancer - the first time anyone has linked the disease's reemergence to specific genetic anomalies. The discovery, co-lead by William L...
Scientists have identified the gene essential for survival of antibody-producing cells, a finding that could lead to better treatments for diseases where these cells are out of control, such as myeloma and chronic immune disorders...
Researchers Reveal Mechanism To Halt Cancer Cell Growth, Discover Potential Therapy
2/06/2013
University of Pittsburgh Cancer Institute (UPCI) researchers have uncovered a technique to halt the growth of cancer cells, a discovery that led them to a potential new anti-cancer therapy. When deprived of a key protein, some cancer cells are unable to properly divide, a finding described in the cover story of the February issue of the Journal of Cell Science...
Some Cancer Mutations Slow Or Stop Tumor Growth
2/05/2013
Just as some mutations in the genome of cancer cells actively spur tumor growth, it would appear there are also some that do the reverse, and act to slow it down or even stop it, according to a new US study led by MIT...
MicroRNA Molecule May Serve As Biomarker, Target For Brain Metastases In Breast Cancer Patients
2/05/2013
MicroRNA molecule called miR-7 decreased in highly metastatic cancer stem-like cells. Researchers have identified two molecules that could potentially serve as biomarkers in predicting brain metastases in patients with breast cancer, according to data published in Cancer Research, a publication of the American Association for Cancer Research...
Prostate Cancer Treatments Often Cause Side Effects
2/05/2013
Prostate Cancer Study Tracks Long-term Urinary, Sexual and Bowel Function Side Effects Following Therapy A new study comparing outcomes among prostate cancer patients treated with surgery versus radiotherapy found differences in urinary, bowel and sexual function after short-term follow-up, but those differences were no longer significant 15 years after initial treatment...
In a significant breakthrough, published last week, scientists prove for the first time that breast cancer stem cells, the driving force of a tumour, can be targeted in cells from patients; an approach that could increase the chances of survival for women with aggressive breast cancers...