Link Discovered Between Blood Clotting And Immune Response
4/03/2013
Rice University researchers have found an unexpected link between a protein that triggers the formation of blood clots and other proteins that are essential for the body's immune system. The find could lead to new treatments for thousands of patients who suffer from inflammatory diseases and disorders that cause abnormal blood clotting. The research is available online in the journal PLOS ONE...
Cymbalta Reduces Chemotherapy Induced Neuropathy
4/03/2013
Duloxetine, an antidepressant, was shown to reduce painful peripheral neuropathy caused by neurotoxic chemotherapy in a study published in JAMA. Researchers from the University of Michigan School of Nursing added that duloxetine benefited the majority of patients in their study...
Inhibiting SRC-3 Could Overcome The Cancer-Promoting Effects Of The Mutations In SPOP
4/03/2013
Mutations in a protein called SPOP (speckle-type POZ protein) disarm it, allowing another protein called steroid receptor coactivator-3 (SRC-3) to encourage the proliferation and spread of prostate cancer cells, said researchers led by those at Baylor College of Medicine in a report that appears online in Proceedings of the National Academy of Sciences...
New Test Kit Enables Effective Treatment For Newly Identified Deadly Lymphoma
4/03/2013
An international research team has identified a new type of deadly intestinal lymphoma that is particularly common in Asia. The team, led by clinician-scientists from the SingHealth Academic Healthcare Cluster, also developed a new diagnostic test to accurately identify these patients...
Bowel Cancer Rates Increase In The UK
4/03/2013
Over the last three and a half decades, the rate of bowel cancer among British men has increased by 30 percent while there's only been a 6 percent increase in women, according to Cancer Research UK. The new data come from the awareness and fundraising campaign carried out by The Bobby Moore Fund...
Duloxetine Reduces Chemo-Induced Neuropathy
4/03/2013
Duloxetine, an antidepressant, was shown to reduce painful peripheral neuropathy caused by neurotoxic chemotherapy in a study published in JAMA. Researchers from the University of Michigan School of Nursing added that duloxetine benefited the majority of patients in their study...
Researchers Warn Against A Potential Backfiring Of Certain Cancer Therapies In Development
4/03/2013
Highly expressed in various cancers and known for its cytoprotective properties, TRAP1 protein has been identified as a potential target for antitumor treatments. As a result of the research conducted by Len Neckers, from the National Cancer Institute in Bethesda, USA, and Didier Picard, from the University of Geneva (UNIGE), Switzerland, this outlook is now being called into question...
Novel Brain Cancer Treatment Uses Genetic Material From Bone Marrow Cells
4/03/2013
In a first-of-its-kind experiment using microvesicles generated from mesenchymal bone marrow cells (MSCs) to treat cancer, neurological researchers at Henry Ford Hospital have discovered a novel approach for treatment of tumor...
Cisplatin-Resistant Cancer Cells Sensitive To Experimental Anticancer Drugs Called PARP Inhibitors
4/03/2013
Cisplatin-resistant non-small cell lung cancer cells expressed high levels of hyperactivated PARP1. Cells succumbed to PARP inhibitors in vitro. PARP inhibitor slowed cisplatin-resistant tumor growth in mice...
Studying The Epigenetics Of Hormone Therapy Resistance Leads To New Drug Target
4/03/2013
A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant...