Promising Early Results For Use Of Poliovirus Vaccine In Recurrent Glioblastoma
5/24/2013
An attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study to establish the proper dose level, researchers at Duke Cancer Institute report...
Superiority Of Bivalirudin Over Heparin Questioned
5/24/2013
Results from a large observational study reported at EuroPCR 2013 question whether bivalirudin is superior to heparin in the absence of GPIIb/IIIa blockade, showing similar 30-day mortality in patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS) undergoing percutaneous coronary intervention (PCI)...
Frequent Heartburn Increases Risk Of Throat Cancer By 78%
5/24/2013
Frequent heartburn increases the risk of cancers of the throat and vocal cord among nondrinkers and nonsmokers, according to a new study. The research, published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, also indicated that the use of antacids has a protective effect against these cancers, while prescription medications do not...
New Tumour Killer Developed By Scientists
5/24/2013
Scientists from Nanyang Technological University (NTU) and Lund University, Sweden, have bioengineered a novel molecule which has been proven to successfully kill tumour cells. This molecule is based on a natural protein present in human breast milk, which has been found to have strong and wide-ranging tumour killing properties when bound to certain lipids...
By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces metastatic spread in mouse models of prostate, breast and lung cancer...
Fighting Ovarian Cancer With Gold Nanoparticles
5/23/2013
Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Mayo Clinic researchers found out why and determined how to make the nanoparticles effective against ovarian cancer cells. The discovery is detailed in the current online issue of the Journal of Biological Chemistry...
Gene Expression Analysis Of Colorectal Cancer
5/23/2013
A novel transcriptome-based classification of colon cancer that improves the current disease stratification based on clinicopathological variables and common DNA markers is presented in a study published in PLOS Medicine this week. (A transcriptome is all RNA produced by a population of cells.) Pr...
Grapefruit-Derived Nanovectors Provide A Secret Weapon In Medical Drug Delivery
5/23/2013
University of Louisville researchers have uncovered how to create nanoparticles using natural lipids derived from grapefruit, and have discovered how to use them as drug delivery vehicles. UofL scientists Huang-Ge Zhang, D.V.M., Ph.D., Qilong Wang, Ph.D., and their team have published their findings in Nature Communications. Lipids derived from grapefruit...
In Non-Small Cell Lung Cancer, Racial Disparities Found In Surgical Management
5/23/2013
The surgical management of non-small cell lung cancer (NSCLC) in U.S. hospitals varies widely depending on the race of the patient, according to a new study. "In most patients, the initial treatment for Stage I and Stage II NSCLC is surgery," said researcher Jayanth Adusumalli, MBBS, of the Creighton University Medical Center in Omaha, Nebraska...
Researchers Develop Model For Better Testing, Targeting Of MPNST
5/23/2013
Researchers from the Masonic Cancer Center, University of Minnesota, and the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral nerve sheath tumors (MPNST) that allow them to discover new genes and gene pathways driving this type of cancer. The research was published this week in the journal Nature Genetics...