Potential New Clues For Identifying Breast Cancer Risk
6/06/2013
New research provides critical insights into how normal breast precursor cells may be genetically vulnerable to develop into cancer. The research is published in the inaugural issue of Stem Cell Reports, an open-access journal from the International Society of Stem Cell Research (ISSCR) published by Cell Press...
Genetic Variations Impact Warfarin Doses For African Americans
6/06/2013
A common genetic variation that can impact the therapeutic dose of the blood-thinning drug warfarin among African Americans has been found, according to a new report in The Lancet...
New Strategy For Defeating Neuroblastoma
6/05/2013
Researchers at Karolinska Institutet in Sweden have found a promising strategy for defeating neuroblastoma - a malignant form of cancer in children - that focuses on the so-called MYCN protein. A specific chemical molecule helps to break down MYCN, which either kills the cancer cell or makes it mature into a harmless neuron...
New Drug Target Identified In Deadly Form Of Leukemia
6/05/2013
A research team led by the Duke-NUS Graduate Medical School (Duke-NUS) in Singapore has identified ways to inhibit the function of a key protein linked to stem cell-like behavior in terminal-stage chronic myeloid leukemia (CML), making it possible to develop drugs that may extend the survival of these patients...
Genetic Signature Of Deadly Brain Cancer Identified
6/05/2013
A multi-institutional team of researchers have pinpointed the genetic traits of the cells that give rise to gliomas - the most common form of malignant brain cancer. The findings, which appear in the journal Cell Reports, provide scientists with rich new potential set of targets to treat the disease...
How And Where Breast Tumor Cells Become Dormant And What Causes Them To Become Metastatic
6/05/2013
The long-standing mystery behind dormant disseminated breast tumor cells and what activates them after years and even decades of latency may have been solved. Researchers with the U.S...
Cancer Survivors And Partners More Prone To Anxiety Than Depression
6/05/2013
Long-term cancer survivors are not at a much higher risk of developing depression compared with healthy people, but they are more likely to experience anxiety. The finding was published today in The Lancet Oncology and outlines that not only are the survivors at risk for anxiety, but their partners face similar levels of depression and higher levels of anxiety than the survivors themselves...
New Oncogene And Potential Target In Lung Cancer: RET Rearrangement
6/05/2013
In results presented at ASCO 2013, a University of Colorado Cancer Center study provided important details for a recently identified driver and target in lung adenocarcinoma: rearrangement of the gene RET. The finding is an important step along a trajectory like that which led to FDA approval of the drug crizotinib, which targets a somewhat similar rearrangement in the ALK gene...
Genetic Screening Declined By Many Despite Good Prognosis
6/05/2013
Even if Australians with newly diagnosed bowel cancer were routinely tested for a genetic predisposition to further cancers, one in three people would still not take the necessary steps to use that information to prevent further disease...
Cancer Survivors And Their Partners At Greater Risk Of Anxiety, Not Depression
6/05/2013
Long-term cancer survivors are not at a much higher risk of developing depression compared with healthy people, but they are more likely to experience anxiety. The finding was published today in The Lancet Oncology and outlines that not only are the survivors at risk for anxiety, but their partners face similar levels of depression and higher levels of anxiety than the survivors themselves...