Pathways Identified That Lead To Creation Of Myofibroblasts, That Cause Destructive Runaway Scarring
7/03/2013
Scientists have tracked down and quantified the diverse origins of cells that drive fibrosis, the incurable, runaway wound-healing that scars and ultimately destroys organs such as the lungs, liver and kidneys...
Dysfunction of the ubiquitin-proteasome system is related to many severe neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and certain types of cancer. Such dysfunction is also believed to be related to some degenerative muscle diseases...
New Evidence For The Genetic Bases Of Liver Cancer
7/03/2013
The Asian Cancer Research Group (ACRG), an independent, not-for-profit company in collaboration with BGI, the world's largest genomics organization, and The University of Hong Kong (HKU), jointly announced the publication of findings from a study of recurrent mutations in hepatocellular carcinoma (HCC), one of the most deadly cancers worldwide, in the international journal Genome Research ...
Research Report Breakthrough In The Regulation Of A Key Cancer Drug Target
7/03/2013
There's not much difference between what makes a man and what makes his beer - at least at the molecular level - according to a new study led by Professor John Schwabe at the University of Leicester. Scientists used a powerful technique called protein crystallography to look at 3D structures of protein complexes purified from cultured human cells...
Autophagy Protects Neuroblastoma From Chemotherapy
7/03/2013
Neuroblastomas are pediatric tumors that originate from cells of the embryonic nervous system. The disease can take widely varying clinical courses that range from spontaneous regression to fatal outcomes. Highly aggressive neuroblastomas rarely respond well to chemotherapy...
News From The Annals Of Internal Medicine: 2 July 2013
7/03/2013
1. Salsalate Proves Effective for Type 2 Diabetes Salsalate, a prodrug form of salicylate, may be an effective treatment for patients with type 2 diabetes but its efficacy and safety have not been tested using currently accepted regulatory practices...
When The Body Turns Traitor And Aids And Abets The Spread Of Cancer
7/03/2013
The very system that is meant to protect the body from invasion may be a traitor. These new findings of a study, led by investigators at the Research Institute of the McGill University Health Centre (RI-MUHC), reveal that infection-fighting white blood cells play a role in activating cancer cells and facilitating their spread to secondary tumours...
Physicist Suggest That Cancer May Be A Result Of A Default Cellular 'Safe Mode'
7/03/2013
Death rates from cancer have remained largely unchanged over the past 60 years. A physicist is trying to shed more light on the disease with a very different theory of its origin that traces cancer back to the dawn of multicellularity more than a billion years ago...
Autologous HSC Transplant May Treat Sickle Cell Disease
7/03/2013
Sickle cell disease (SCD) is an autosomal recessive disorder caused by mutations in hemoglobin (HBB) that deform red blood cells. A small number of patients have been successfully treated with allogeneic hematopoietic stem cell (HSC) transplantation; however, there are several drawbacks and complications associated with this procedure, including graft vs...
Lessons Learned About Anticoagulants From A Tick's Spit
7/03/2013
There really is such a thing as tick spit - that is, the saliva of a tick. And there's something about it that might help fight heart disease and stroke. The link comes from a protein found in the spit of ixodes (ik-SO-deez) ticks, which are also known as blacklegged ticks, or deer ticks. These kinds of ticks tear their way into skin and feed on their host's blood for several days...