Gynecologic surgery patients benefit from enhanced recovery pathway
8/29/2013
Patients who had complex gynecologic surgery managed by an enhanced recovery pathway (ERP) resulted in decreased narcotic use, earlier discharge, stable readmission rates, excellent patient satisfaction and cost savings, according to a Mayo Clinic study. The findings are published in the journal Obstetrics & Gynecology...
Microarray-based gene expression profiling reveals 3 subtypes of gastric cancer
8/29/2013
Stomach cancer, one of the leading causes of cancer death worldwide, actually falls into three broad subtypes that respond differently to currently available therapies, according to researchers at Duke-NUS Graduate Medical School Singapore...
Gynecologic surgery patients benefit from enhanced recovery pathway
8/29/2013
Patients who had complex gynecologic surgery managed by an enhanced recovery pathway (ERP) resulted in decreased narcotic use, earlier discharge, stable readmission rates, excellent patient satisfaction and cost savings, according to a Mayo Clinic study. The findings are published in the journal Obstetrics & Gynecology...
Skin cancer an increased risk for recipients of donor kidneys
8/29/2013
Patients that receive kidney transplants have an increased risk of an invasive form of skin cancer. It is unclear if donor tissue contributes to cancer formation. In this issue of the Journal of Clinical Investigation, Philippe Ratajczak and colleagues at INSERM demonstrate that donor tissue can lead to cancer formation in transplant recipients...
New research in the Journal of Clinical Investigation suggests that blocking a protein normally credited with suppressing leukemia may be a promising therapeutic strategy for an aggressive form of the disease called acute myeloid leukemia (AML). Researchers from Cincinnati Children's Hospital Medical Center report their results in a study posted online by the journal...
For colorectal cancer patients at VA, wait times up 78 percent
8/29/2013
A study published in the August print issue of the Journal of Oncology Practice shows that from 1998-2008, wait times for colorectal cancer operations at Veterans Administration hospitals increased from 19 to 32 days. But researchers think longer waits may be a reflection of several unmeasured variables including more careful care, staffing, and patient conditions or preferences...
Some stem cells are more susceptible to cancer than others
8/29/2013
Cells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones. Learning about the nature of tissue stem cells can help scientists understand exactly how our organs are built, and why some organs generate cancer frequently, but others only rarely...
Combating drug-resistant cancers
8/29/2013
Many cancer therapies function by activating proteins like Caspase-3 (CASP3) that promote cell death. Several forms of cancer develop resistance to these drugs by down regulating CASP3 through an unknown mechanism. In the absence of CASP3, tumor cells produce another cell death promoting protein CASP7, but it is rendered inactive by the X-linked inhibitor of apoptosis protein (XIAP)...
Software tool developed for cancer genomics
8/29/2013
Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics. Xing Hua, Ph.D...
Genomic sequencing leads to discovery of origin of hereditary east Texas bleeding disorder
8/29/2013
A severe hereditary bleeding disorder was described in a large family from east Texas in 2001. The affected family members routinely had bruising, nosebleeds, massive blood loss following injury or surgery, and often required blood transfusions. Routine tests for functional components of the blood coagulation pathway did not reveal any obvious defects...