Unusual combination therapy shows promise for preventing prostate cancer, UPCI researchers find
9/18/2013
Combining a compound from broccoli with an antimalarial drug prevents prostate cancer in mice, University of Pittsburgh Cancer Institute (UPCI) researchers discovered. The National Cancer Institute-funded research will be published in the Oct. 1 issue of the journal Cancer Research...
Researchers identify mechanisms that oversee the development of a pro-tumor network
9/18/2013
Researchers at Roswell Park Cancer Institute (RPCI) have uncovered a new pathway by which cancer cells, such as in breast cancer, stimulate the expansion of myeloid-derived suppressor cells (MDSCs), a blood cell population known to interfere with the body's anti-tumor response...
Vanderbilt study targets DNA of cancer cell drug resistance
9/18/2013
Targeted cancer therapies - drugs that kill cancer cells with certain "driver oncogenes" - shrink tumors and extend patient survival. Ultimately though, the cancers become resistant to the targeted therapies. "Unfortunately, virtually all patients with metastatic cancer develop disease progression, limiting the effectiveness of these agents," said William Pao, M.D., Ph.D...
UC Davis study applies timely cost-effectiveness analysis to state breast cancer screening program
9/18/2013
When public health budgets are constrained, mammography screening should begin later and occur less frequently, a cost-effectiveness analysis for California's Every Woman Counts (EWC) program concludes...
Gene therapy study produces promising results for patients with hemophilia B
9/18/2013
A fraction of patients with a common form of the bleeding disorder hemophilia develop an allergic reaction to the blood-clotting treatment they need to keep them alive...
Researchers identify new target for melanoma treatment
9/18/2013
Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have announced the discovery that a gene encoding an enzyme, phosphoinositide-dependent kinase-1 (PDK1), plays an essential role in the development and progression of melanoma. The finding offers a new approach to treating this life-threatening disease. The team of researchers, led by Ze'ev Ronai, Ph.D...
Cancer cell growth encouraged by specific sugar molecule
9/18/2013
The process of glycosylation, where sugar molecules are attached to proteins, has long been of interest to scientists, particularly because certain sugar molecules are present in very high numbers in cancer cells. It now turns out that these sugar molecules are not only present but actually aid the growth of the malignant cells...
Researchers at the Virginia Tech Carilion Research Institute have reported the first experimental evidence that supports the theory that a soccer ball-shaped nanoparticle commonly called a buckyball is the result of a breakdown of larger structures rather than being built atom-by-atom from the ground up...
Fear drives young cancer patients to needless mastectomies
9/17/2013
After being diagnosed with cancer in one breast, many young women opt to have the other healthy breast removed with a procedure called contralateral prophylactic mastectomy (CPM), despite knowing that it will probably not improve chances of survival, a new study shows. Researchers from the Dana-Faber Cancer Institute published their results in the journal Annals of Internal Medicine...
New marker identified for early diagnosis of lung cancer
9/17/2013
A protein called isocitrate dehydrogenase (IDH1) is present at high levels in lung cancers and can be detected in the blood, making it a noninvasive diagnostic marker for lung cancers, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research...