Researchers at A*STAR's Singapore Immunology Network (SIgN) have discovered a new mechanism involving p53, the famous tumour suppressor, to fight against aggressive cancers. This strategy works by sabotaging the ability of the cancer cells to hide from the immune system...
Hormone fluctuations, immune cells and breast cancer risk
9/23/2013
University of Adelaide researchers have made a major discovery that highlights the important role played by immune cells in the risk of developing breast cancer. Researchers have focused their efforts on immune cells known as macrophages in the breast, and how the role of these cells changes because of fluctuations in hormones during different times of the month...
Tackling drug-resistant cancers using a genome-forward approach
9/23/2013
If you really want to understand why a particular human cancer resists treatment, you have to be able to study that tumor - really study it - in a way that just isn't possible in humans. Cancer biologists have been developing a new approach to this challenge, by transplanting human cancers directly from patients to mice whose crippled immune systems will allow those human tissues to grow...
Like normal cells, cancer cells require amino acids for growth, maintenance, and cell signaling, and L-type amino acid transporters (LATs) are the delivery vehicles that supply them...
New technique helps bring genome's 'dark matter' into the light
9/22/2013
Using technology he helped develop, Vanderbilt University scientist Bryan Venters, Ph.D., has shed new light on the "dark matter" of the genome and has begun to explore a possible new approach to treating cancer...
Like normal cells, cancer cells require amino acids for growth, maintenance, and cell signaling, and L-type amino acid transporters (LATs) are the delivery vehicles that supply them...
New technique helps bring genome's 'dark matter' into the light
9/22/2013
Using technology he helped develop, Vanderbilt University scientist Bryan Venters, Ph.D., has shed new light on the "dark matter" of the genome and has begun to explore a possible new approach to treating cancer...
Investigators at Cold Spring Harbor Laboratory (CSHL) have reported important progress in research aimed at finding ways to fight cancer by targeting the local environment in which tumors grow and from which they draw sustenance...
Steady energy supply to cells during times of fasting ensured by circadian clock
9/22/2013
Each of our cells has an energy furnace, and it is called a mitochondrion. A Northwestern University-led research team now has identified a new mode of timekeeping that involves priming the cell's furnace to properly use stored fuel when we are not eating. The interdisciplinary team has identified the "match" and "flint" responsible for lighting this tiny furnace...
Findings provide insights for new, targeted myeloma therapies in clinical trials
9/20/2013
Researchers have discovered why multiple myeloma, a difficult to cure cancer of the bone marrow, frequently recurs after an initially effective treatment that can keep the disease at bay for up to several years...