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NCI News

Four multinational, interdisciplinary teams selected to address major challenges in cancer

The Cancer Grand Challenges Program will award $100 million to four interdisciplinary teams from around the world to solve some of the toughest challenges in cancer research. Each team will receive $25 million over 5 years.

In people with HIV, treating precancerous anal lesions cuts risk of anal cancer by more than half

Results from the NCI-supported ANCHOR study show that treating anal precancerous growths known as high-grade squamous intraepithelial lesions, or HSIL, reduces the chance that anal cancer will develop by more than half.

Cancer death rates among Black people declined over time, but remain higher than other racial and ethnic groups

From 1999—2019, US rates of cancer death fell among Black people. Yet, in 2019, their rates remained higher than those of other racial and ethnic groups.

Uterine cancer deaths are rising in the United States, and are highest among Black women

Deaths from uterine cancer are rising in the United States, and are highest among non-Hispanic Black women, according to a new study led by researchers at NCI, part of the National Institutes of Health. The higher death rates are related to the rising incidence of aggressive subtypes of uterine cancer.

Norman Sharpless steps down as director of the National Cancer Institute

Norman E. “Ned” Sharpless, M.D., announces his decision to step down as NCI director, a position he has held since 2017. NCI Principal Deputy Director Douglas R. Lowy, M.D., will serve as NCI’s acting director beginning April 30, 2022.

NCI launches program to offer molecular characterization of childhood cancers

The Molecular Characterization Initiative will offer state-of-the-art diagnoses to children, adolescents, and young adults with central nervous system tumors.

Gene expression profile could enable rapid identification of anti-tumor immune cells for personalized immunotherapy

NCI researchers have found unique expression profiles in 50 genes that help identify rare anti-tumor lymphocytes that can infiltrate and help defeat metastatic solid epithelial tumors.

NCI study advances personalized immunotherapy for metastatic breast cancer

NCI researchers have shown that an experimental form of immunotherapy that uses an individual’s own tumor-fighting immune cells could potentially be used to treat people with metastatic breast cancer who have exhausted all other treatment options.

A high-fiber diet may improve the response of melanoma patients to immunotherapy

NCI researchers have found that a diet rich in fiber may help some people being treated for melanoma respond to immunotherapy treatment by influencing the gut microbiome. The new findings come from an analysis of people with melanoma and mouse models of the disease.

Drug combination helps children with acute promyelocytic leukemia avoid conventional chemotherapy

A Children’s Oncology Group trial shows that the combination of all-trans retinoic acid and arsenic trioxide is highly effective in children with acute promyelocytic leukemia. The therapy avoids or minimizes the use of conventional chemotherapy.